在Wistar大鼠中进行的[具体物质]90天重复剂量口服毒性研究。 （原文中“of”后面缺少具体物质名称）
Ninety days repeated dose oral toxicity study of in Wistar rats.
作者信息
Jamadagni Shrirang, Jamadagni Pallavi Shrirang, Singh Rajendra Kumar, Upadhyay Sachchidanand, Gaidhani Sudesh N, Hazra Jayram
机构信息
Department of Pharmacology, Central Ayurveda Research Institute of Drug Development, Kolkata, West Bengal, India.
Department of Pharmacology, Central Council for Research in Ayurvedic Sciences, Ministry of AYUSH, New Delhi, India.
出版信息
Ayu. 2017 Jul-Dec;38(3-4):171-178. doi: 10.4103/ayu.AYU_33_17.
CONTEXT
is a . Since it contains two heavy metals, namely mercury and gold, it is essential to evaluate its safety. Hence, the present study was undertaken with an objective to evaluate toxicity and target organ of toxicity of if so.
AIMS
The objective was to evaluate toxicological profile, the target organ of toxicity and to find no observed effect level (NOEL) or no observed adverse effect level (NOAEL) in rats after oral administration for ninety consecutive days.
MATERIALS AND METHODS
preparation was administered to male and female Wistar rats for ninety consecutive days at 2.7, 13.5, and 27 mg/kg body weight. All relevant biochemical and hematological changes were observed. At termination, all the rats were sacrificed and necropsy was performed. Histopathological evaluation was also performed.
STATISTICAL ANALYSIS USED
Dunnett's test followed by analysis of variance.
RESULTS
There was a significant increase in high-dose group kidney weight of both sexes which could not be correlated with histopathology findings and serum biochemistry. Therefore, the change was not considered as an adverse effect.
CONCLUSIONS
The dose level 27 mg/kg of was found as NOAEL and dose level 13.5 mg/kg of was found as NOEL.
背景
是一种……。由于它含有两种重金属，即汞和金，因此评估其安全性至关重要。因此，本研究旨在评估其毒性及毒性靶器官（如果存在的话）。
目的
目的是评估连续90天经口给予大鼠后的毒理学概况、毒性靶器官，并确定未观察到效应水平（NOEL）或未观察到有害效应水平（NOAEL）。
材料与方法
以2.7、13.5和27mg/kg体重的剂量连续90天给予雄性和雌性Wistar大鼠。观察所有相关的生化和血液学变化。实验结束时，处死所有大鼠并进行尸检。还进行了组织病理学评估。
所用统计分析方法
采用方差分析后进行Dunnett检验。
结果
高剂量组两性大鼠的肾脏重量均显著增加，但这与组织病理学结果和血清生化指标无关。因此，该变化不被视为有害效应。
结论
发现27mg/kg剂量的为NOAEL，13.5mg/kg剂量的为NOEL。
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