Shahbaz Amir, Fransawy Alkomos Mina, Mahendhar Rupak, Nabi Usman, Riaz Maria, Sachmechi Issac
Internal Medicine, Icahn School of Medicine at Mount Sinai/Queen Hospital Center, New York, USA.
Research, California Institute of Behavioral Neurosciences & Psychology, Sacramento, USA.
Cureus. 2018 Jul 20;10(7):e3014. doi: 10.7759/cureus.3014.
Follicular variant of papillary thyroid carcinoma (FVPTC) presented as an autonomous functioning thyroid nodule is a rare finding. We reported a case of 70-year-old male presented with complaints of palpitation and heat intolerance. On palpation, we found a thyroid nodule of 4 cm in the left lobe. Thyroid function tests revealed hyperthyroidism, and radioactive iodine uptake scan (RAIU) showed increased uptake in the left lobe consistent with a hot nodule. The probability of the benign nature of hyperfunctioning thyroid nodule discussed but patient requested further workup to rule out any remote possibility of thyroid cancer. We performed a fine needle aspiration (FNA), and the cytological examination suggested the possibility of thyroid carcinoma. The patient underwent total thyroidectomy, and histological examination revealed follicular architecture with nuclear features of papillary carcinoma in 1 cm area of the thyroid nodule. In the review of the literature, we identified the following seven cases of FVPTC arising within a hyperfunctioning thyroid nodule.
表现为自主功能性甲状腺结节的甲状腺乳头状癌滤泡亚型（FVPTC）是一种罕见的发现。我们报告了一例70岁男性，主诉心悸和不耐热。触诊时，我们在左叶发现一个4厘米的甲状腺结节。甲状腺功能检查显示甲状腺功能亢进，放射性碘摄取扫描（RAIU）显示左叶摄取增加，与热结节一致。讨论了高功能甲状腺结节为良性的可能性，但患者要求进一步检查以排除甲状腺癌的任何潜在可能性。我们进行了细针穿刺抽吸（FNA），细胞学检查提示甲状腺癌的可能性。患者接受了全甲状腺切除术，组织学检查显示甲状腺结节1厘米区域内具有乳头状癌核特征的滤泡结构。在文献回顾中，我们确定了以下7例发生在高功能甲状腺结节内的FVPTC病例。
