阴道雌三醇联合促性腺激素释放激素激动剂疗法在全腹腔镜子宫切除术中的应用效果
Effect of Vaginal Estriol Use in Total Laparoscopic Hysterectomy with Gonadotropin-Releasing Hormone Agonist Therapy.
作者信息
Hirata Go, Yoshida Hiroshi, Furuno Atsuko, Kitagawa Masakazu, Sakakibara Hideya
机构信息
Department of Gynecology, Yokohama City University Medical Center, Yokohama, Kanagawa, Japan.
Department of Gynecology and Obstetrics, Yokohama Municipal Citizen's Hospital, Yokohama, Kanagawa, Japan.
出版信息
Gynecol Minim Invasive Ther. 2018 Jul-Sep;7(3):114-118. doi: 10.4103/GMIT.GMIT_57_18. Epub 2018 Aug 23.
STUDY OBJECTIVES
The aim of this study is to evaluate the effects of vaginal estriol therapy in total laparoscopic hysterectomy (TLH) with gonadotropin-releasing hormone agonist (GnRH-a) treatment.
DESIGN
Retrospective analysis.
DESIGN CLASSIFICATION
Canadian Task Force classification II-2.
SETTINGS
Department of Gynecology, Yokohama City University Medical Center, Japan.
METHODS
We retrospectively investigated 50 fibroid cases that had TLH with preoperative GnRH-a treatment and compared the surgical outcome with or without vaginal estriol use (1mg). Estriol was used administered for two weeks before TLH.
MEASUREMENTS AND MAIN RESULTS
A total of 12 patients (27%) received vaginal estriol (1 mg) for 14 days before TLH. As a result of vaginal estriol treatment, there were no group differences in uterus size reduction with GnRH-a treatment (22% vs. 15%, = 0.20), uterine removal time through the vagina (12.5 min vs. 18.5 min, = 0.18), rate of vaginal dehiscence (3% vs. 0%, = 0.76) or in the rate of perineal laceration (33% vs. 34%, = 0.55).
CONCLUSION
The use of vaginal estriol treatment before TLH with GnRH-a therapy did not improve surgical outcomes.
研究目的
本研究旨在评估阴道雌三醇疗法联合促性腺激素释放激素激动剂（GnRH-a）治疗在全腹腔镜子宫切除术（TLH）中的效果。
设计
回顾性分析。
设计分类
加拿大工作组分类II-2。
地点
日本横滨市立大学医学中心妇科。
方法
我们回顾性调查了50例接受术前GnRH-a治疗并行TLH的子宫肌瘤病例，并比较了使用或未使用阴道雌三醇（1mg）的手术结果。在TLH前两周使用雌三醇。
测量指标及主要结果
共有12例患者（27%）在TLH前14天接受阴道雌三醇（1mg）治疗。阴道雌三醇治疗后，GnRH-a治疗导致的子宫缩小情况（22%对15%，P = 0.20）、经阴道子宫切除时间（12.5分钟对18.5分钟，P = 0.18）、阴道裂开率（3%对0%，P = 0.76）或会阴裂伤率（33%对34%，P = 0.55）在两组间均无差异。
结论
在TLH联合GnRH-a治疗前使用阴道雌三醇治疗并不能改善手术结果。
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