Singapore Immunology Network A*STAR, Singapore.
Wiley Interdiscip Rev Syst Biol Med. 2019 Jan;11(1):e1438. doi: 10.1002/wsbm.1438. Epub 2018 Sep 25.
Mammalian barrier surfaces are densely populated by symbiont fungi in much the same way the former are colonized by symbiont bacteria. The fungal microbiota, otherwise known as the mycobiota, is increasingly recognized as a critical player in the maintenance of health and homeostasis of the host. Here we discuss the impact of the mycobiota on host physiology and disease, the factors influencing mycobiota composition, and the current technologies used for identifying symbiont fungal species. Understanding the tripartite interactions among the host, mycobiota, and other members of the microbiota, will help to guide the development of novel prevention and therapeutic strategies for a variety of human diseases. This article is categorized under: Physiology > Mammalian Physiology in Health and Disease Laboratory Methods and Technologies > Genetic/Genomic Methods Models of Systems Properties and Processes > Organismal Models.
哺乳动物的屏障表面上栖息着大量共生真菌，就像其表面上栖息着大量共生细菌一样。真菌菌群，也被称为菌丛，越来越被认为是宿主健康和体内平衡维持的关键因素。在这里，我们讨论了菌丛对宿主生理学和疾病的影响、影响菌丛组成的因素以及用于鉴定共生真菌物种的当前技术。了解宿主、菌丛和其他微生物群成员之间的三方相互作用，将有助于指导针对各种人类疾病的新型预防和治疗策略的制定。本文属于以下分类：生理学 > 健康和疾病中的哺乳动物生理学 实验室方法和技术 > 遗传/基因组方法 系统属性和过程的模型 > 生物体模型。
