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腹腔镜结肠手术后转换对主要并发症风险的影响:一项国际多中心前瞻性审计。

The impact of conversion on the risk of major complication following laparoscopic colonic surgery: an international, multicentre prospective audit.

机构信息

European Society of Coloproctology (ESCP) Cohort Studies Committee, Department of Colorectal Surgery, University of Birmingham, Birmingham, UK.

出版信息

Colorectal Dis. 2018 Sep;20 Suppl 6:69-89. doi: 10.1111/codi.14371.

Abstract

BACKGROUND

Laparoscopy has now been implemented as a standard of care for elective colonic resection around the world. During the adoption period, studies showed that conversion may be detrimental to patients, with poorer outcomes than both laparoscopic completed or planned open surgery. The primary aim of this study was to determine whether laparoscopic conversion was associated with a higher major complication rate than planned open surgery in contemporary, international practice.

METHODS

Combined analysis of the European Society of Coloproctology 2017 and 2015 audits. Patients were included if they underwent elective resection of a colonic segment from the caecum to the rectosigmoid junction with primary anastomosis. The primary outcome measure was the 30-day major complication rate, defined as Clavien-Dindo grade III-V.

RESULTS

Of 3980 patients, 64% (2561/3980) underwent laparoscopic surgery and a laparoscopic conversion rate of 14% (359/2561). The major complication rate was highest after open surgery (laparoscopic 7.4%, converted 9.7%, open 11.6%, P < 0.001). After case mix adjustment in a multilevel model, only planned open (and not laparoscopic converted) surgery was associated with increased major complications in comparison to laparoscopic surgery (OR 1.64, 1.27-2.11, P < 0.001).

CONCLUSIONS

Appropriate laparoscopic conversion should not be considered a treatment failure in modern practice. Conversion does not appear to place patients at increased risk of complications vs planned open surgery, supporting broadening of selection criteria for attempted laparoscopy in elective colonic resection.

摘要

背景

腹腔镜手术现已在全球范围内成为结直肠切除术的常规治疗方法。在采用腹腔镜手术的过程中,研究表明中转开腹可能对患者不利,中转患者的结局不如腹腔镜手术或计划的开放手术。本研究的主要目的是确定在当代国际实践中,腹腔镜中转是否与计划的开放手术相比,具有更高的主要并发症发生率。

方法

对欧洲结直肠外科学会 2017 年和 2015 年的审计进行联合分析。纳入接受择期结直肠段切除并进行一期吻合的患者,从盲肠到直肠乙状结肠交界处。主要结局指标为 30 天主要并发症发生率,定义为 Clavien-Dindo 分级 III-V 级。

结果

在 3980 例患者中,64%(2561/3980)接受腹腔镜手术,腹腔镜中转率为 14%(359/2561)。开放手术后的主要并发症发生率最高(腹腔镜 7.4%,中转 9.7%,开放 11.6%,P<0.001)。在多层次模型中进行病例混合调整后,只有计划的开放(而非腹腔镜中转)手术与腹腔镜手术相比,与增加的主要并发症相关(OR 1.64,1.27-2.11,P<0.001)。

结论

在现代实践中,适当的腹腔镜中转不应被视为治疗失败。与计划的开放手术相比,中转似乎不会增加患者发生并发症的风险,支持在择期结肠切除术中放宽尝试腹腔镜手术的选择标准。

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