InsightRX, San Francisco, California, USA.
Department of Pharmacy & Radboud Applied Pharmacometrics Group, Radboudumc, Nijmegen, The Netherlands.
CPT Pharmacometrics Syst Pharmacol. 2018 Dec;7(12):785-787. doi: 10.1002/psp4.12353. Epub 2018 Oct 16.
The development of model-informed precision dosing (MIPD) tools, especially in the form of native or web-based applications to be used at the bedside, has garnered marked attention in recent years. Their potential clinical benefit can be large, but it should be ensured that such tools make optimal use of available clinical data and have adequate predictive ability. Unique scientific challenges specific to MIPD remain, which may require adaptation of commonly used diagnostics in pharmacometrics.
近年来，模型指导的精准给药（MIPD）工具的发展，特别是以本地或基于网络的应用程序形式，在床边使用，引起了广泛关注。这些工具具有潜在的临床应用价值，但应该确保它们能够充分利用现有临床数据并具有足够的预测能力。MIPD 还存在独特的科学挑战，可能需要对药物代谢动力学中常用的诊断方法进行适应性调整。
