Wang Yifei
Animal Science College, Tibet Agriculture & Animal Husbandry University, Linzhi 860000, Tibet, China.
Sheng Wu Gong Cheng Xue Bao. 2018 Sep 25;34(9):1453-1459. doi: 10.13345/j.cjb.180189.
Hepatitis E virus (HEV) infection is a main global public health issue. HEV can be zoonotically transmitted across species, and swine is recognized as a major reservoir of HEV. However, information is lacking on the prevalence of HEV infection in Tibet of China, where raw pork and mixed farming of different species of domestic animals are consumed traditionally. In this study, swine serum was collected for HEV IgM and IgG antibodies test from five regions in Tibet of China. Meanwhile, HEV RNA was detected in swine sera. HEV has a high prevalence trend in Tibetan swine. Swine serum anti-HEV IgM antibody positive rate was as high as 7.6%, the positive rate of anti-HEV IgG antibody was 1.8%, the positive rate of HEV RNA also was 7.6%, the virus titers in serum was above 1.7×10⁷ copies/mL, and there were different epidemic trends in five regions. In conclusion, antibody detection and RNA detection showed that swine in Tibet had a higher incidence of HEV infection. HEV infection in Tibetan swine is more serious and management should be strengthened to avoid cross-infection between humans and animals and outbreaks in Tibet.
戊型肝炎病毒（HEV）感染是一个主要的全球公共卫生问题。HEV可通过人畜共患病的方式在物种间传播，猪被认为是HEV的主要宿主。然而，在中国西藏地区，传统上有食用生猪肉和不同家畜混养的情况，关于该地区HEV感染的流行情况却缺乏相关信息。在本研究中，从中国西藏的五个地区采集猪血清，用于检测HEV IgM和IgG抗体。同时，在猪血清中检测HEV RNA。HEV在西藏猪群中有较高的流行趋势。猪血清抗HEV IgM抗体阳性率高达7.6%，抗HEV IgG抗体阳性率为1.8%，HEV RNA阳性率也为7.6%，血清中的病毒滴度高于1.7×10⁷拷贝/毫升，且五个地区存在不同的流行趋势。总之，抗体检测和RNA检测表明，西藏猪群中HEV感染发生率较高。西藏猪群中的HEV感染更为严重，应加强管理以避免人畜之间的交叉感染以及西藏地区的疫情爆发。
