Gravena Angela Andréia França, Romeiro Lopes Tiara Cristina, Demitto Marcela de Oliveira, Borghesan Deise Helena Pelloso, Dell’ Agnolo Cátia Millene, Brischiliari Sheila Cristina Rocha, Carvalho Maria Dalva de Barros, Pelloso Sandra Marisa
Department of Health Science, Maringa State University.Av. Colombo 5790, Jd. University, Maringa, Parana, Brazil.Email:
Asian Pac J Cancer Prev. 2018 Sep 26;19(9):2429-2436. doi: 10.22034/APJCP.2018.19.9.2429.
Background: Breast cancer is the most common cancer among women worldwide and the obesity is one of the factors related to the risk of breast cancer mainly in postmenopausal women. This study investigated the association between obesity in pre- and postmenopausal women with the development of breast cancer and the expression of estrogen, progesterone, HeR-2 and triple-negative (TN) receptors. Methods: A case-control study was conducted on 100 patients with recently diagnosed breast cancer and 400 age-matched controls. The women were divided into pre- and post-menopausal groups. Results: The multivariate analysis showed that postmenopausal women with a BMI ≥ 30 kg/m2 at pre-diagnosis and at the most recent measurement were 1.50 (95% CI 1.06-2.13) and 1.56 (95% CI 1.11-2.21) times more likely to develop breast cancer, respectively. These women had a prevalence of obesity of 27.7% when considering pre-diagnosis BMI and 29.4% when analyzing the indicator of recent BMI. When only the cases regarding the presence of obesity with clinicopathological variables were analyzed, a total of 95.2% of the postmenopausal women with pre-diagnostic obesity according to BMI presented the positive estrogen receptor (ER) subtype. Conclusions: In Brazilian women, there is an association between obesity and the risk of breast cancer postmenopause; moreover, there is an association between the occurrence of the positive ER subtype in postmenopausal women and pre-diagnostic obesity according to BMI.
乳腺癌是全球女性中最常见的癌症，肥胖是与乳腺癌风险相关的因素之一，主要发生在绝经后女性中。本研究调查了绝经前和绝经后女性肥胖与乳腺癌发生以及雌激素、孕激素、人表皮生长因子受体2（HER-2）和三阴性（TN）受体表达之间的关联。方法：对100例新诊断的乳腺癌患者和400例年龄匹配的对照进行病例对照研究。这些女性被分为绝经前和绝经后组。结果：多因素分析显示，诊断前和最近一次测量时BMI≥30 kg/m²的绝经后女性患乳腺癌的可能性分别是1.50倍（95%可信区间1.06 - 2.13）和1.56倍（95%可信区间1.11 - 2.21）。考虑诊断前BMI时，这些女性的肥胖患病率为27.7%，分析最近BMI指标时为29.4%。当仅分析肥胖与临床病理变量相关的病例时，根据BMI诊断前肥胖的绝经后女性中，共有95.2%呈现雌激素受体（ER）亚型阳性。结论：在巴西女性中，肥胖与绝经后乳腺癌风险之间存在关联；此外，绝经后女性中ER亚型阳性的发生与根据BMI诊断前肥胖之间存在关联。
