Kwan Andrew, Katz Patricia, Touma Zahi
Queen's University, Kingston, Ontario, Canada.
University of Toronto Lupus Clinic, Toronto Western Hospital, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto, Ontario, Canada.
Curr Rheumatol Rev. 2019;15(2):90-98. doi: 10.2174/1573397114666180926101513.
Depression and anxiety are common neuropsychiatric complaints in patients with Systemic Lupus Erythematosus (SLE). While numerous studies have been performed to investigate the prevalence, impact, and associated factors of depression and anxiety, current literature presents mixed results. In particular, the prevalence of anxiety and depression varies substantially between studies due to methodological limitations, and heterogeneity in defining anxiety and depression, patient selection, and metrics used. Moreover, there is a lack of studies evaluating the validity, reliability, and interpretability of commonly used screening tools for depression and anxiety in SLE patients.
Further investigations should aim to reach a consensus surrounding the role of controversial associated factors in depression and anxiety of SLE patients, while also focusing on the identification of novel factors that have not yet been highlighted in the literature.
抑郁和焦虑是系统性红斑狼疮（SLE）患者常见的神经精神症状。尽管已经开展了大量研究来调查抑郁和焦虑的患病率、影响及相关因素，但目前的文献结果不一。特别是，由于方法学的局限性、焦虑和抑郁定义的异质性、患者选择以及所使用的指标不同，各研究之间焦虑和抑郁的患病率差异很大。此外，缺乏对SLE患者常用抑郁和焦虑筛查工具的有效性、可靠性和可解释性的研究。
进一步的研究应旨在就有争议的相关因素在SLE患者抑郁和焦虑中的作用达成共识，同时也应关注尚未在文献中得到强调的新因素的识别。
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