Golob Majda, Marković Ivan, Zovko Neno, Šakić Davorin, Gudelj-Gračanin Ana, Morović-Vergles Jadranka
Division of Rheumatology and Clinical Immunology, Department of Internal Medicine, School of Medicine, University of Zagreb, Dubrava University Hospital, Zagreb, Croatia.
Division of Physical Medicine and Rehabilitation with Rheumatology, Dubrava University Hospital, Zagreb, Croatia.
Acta Clin Croat. 2018 Mar;57(1):16-21. doi: 10.20471/acc.2018.57.01.02.
The aim of the study was to determine the prevalence of neuropathic pain in knee osteoarthritis patients using painDETECT questionnaire, and to evaluate correlations between pain intensity, gender, age and types of treatment, and the presence of neuropathic pain. The study included 122 patients. All participants completed a questionnaire on sociodemographic data, duration of symp-toms, types of treatment and preventable risk factors (body mass index and waist circumference). The presence of neuropathic pain was assessed by painDETECT, according to which subjects were classified into three groups (neuropathic pain likely, possible, or unlikely). Neuropathic pain was likely in 18 (14.8%), possible in 30 (24.6%) and unlikely in 74 (60.7%) subjects. A significant positive correlation was found between visual analog scale for pain and painDETECT score. There was no statistically significant difference in gender, age, waist circumference and body mass index among three groups of participants according to painDETECT score. In conclusion, knee osteoarthritis patients with neuropathic pain component were experiencing higher levels of pain, implicating poorer pain control with common analgesics. Recognizing these patients as a distinct subgroup would allow clinicians to improve their treatment by using unconventional analgesics with central activity.
本研究的目的是使用疼痛检测问卷确定膝骨关节炎患者中神经性疼痛的患病率，并评估疼痛强度、性别、年龄和治疗类型与神经性疼痛存在之间的相关性。该研究纳入了122名患者。所有参与者均完成了一份关于社会人口统计学数据、症状持续时间、治疗类型和可预防风险因素（体重指数和腰围）的问卷。通过疼痛检测问卷评估神经性疼痛的存在情况，根据该问卷将受试者分为三组（可能存在神经性疼痛、可能存在神经性疼痛或不太可能存在神经性疼痛）。18名（14.8%）受试者可能存在神经性疼痛，30名（24.6%）受试者可能存在神经性疼痛，74名（60.7%）受试者不太可能存在神经性疼痛。疼痛视觉模拟量表与疼痛检测问卷得分之间存在显著正相关。根据疼痛检测问卷得分，三组参与者在性别、年龄、腰围和体重指数方面无统计学显著差异。总之，患有神经性疼痛成分的膝骨关节炎患者疼痛水平较高，这意味着使用普通镇痛药时疼痛控制较差。将这些患者识别为一个独特的亚组将使临床医生能够通过使用具有中枢活性的非常规镇痛药来改善治疗。
