Netherlands Organization for Applied Scientific Research TNO, Leiden, The Netherlands.
Willem-Alexander Children's Hospital, Leiden University Medical Centre, Leiden, The Netherlands.
Acta Paediatr. 2018 Dec;107(12):2125-2130. doi: 10.1111/apa.14596. Epub 2018 Oct 17.
This study aimed to develop a concise tool with acceptable predictive properties to identify young children with specific language impairment (SLI).
In this nested case-control study children with SLI attending two special needs schools for severe speech and language difficulties in the Netherlands were matched by date of birth and sex with control children attending mainstream education. This study analysed the predictive validity for having SLI at a mean age of eight years and three months (range 4-11 years) using combinations of six language milestones that were registered at 24, 36 and 45 months and retrieved from the children's healthcare files in 2012.
We included 253 pairs of children with and without SLI. During a single visit, combinations of two milestones at one age achieved a specificity of at least 97% and sensitivities ranged from 32% to 64%. However, the concise tool, which combined five milestones at three different ages - 24, 36 and 45 months - had a specificity of 96% (95% confidence interval 94-99%) and a sensitivity of 71% (95% confidence interval 66-77%).
Combining milestones at different ages provided a concise tool that could help to detect children with SLI at a young age.
本研究旨在开发一种具有可接受预测性能的简明工具,以识别患有特定语言障碍(SLI)的幼儿。
在这项嵌套病例对照研究中,荷兰两所专门针对严重言语和语言障碍的特殊需要学校的 SLI 儿童按出生日期和性别与接受主流教育的对照儿童相匹配。这项研究分析了在平均年龄为 8 岁零 3 个月(范围为 4-11 岁)时使用 24、36 和 45 个月时登记的 6 项语言里程碑的组合来预测 SLI 的有效性,并从 2012 年儿童保健档案中获取。
我们纳入了 253 对有和没有 SLI 的儿童。在一次就诊中,一个年龄的两个里程碑的组合特异性至少为 97%,敏感性范围为 32%-64%。然而,将三个不同年龄(24、36 和 45 个月)的五个里程碑组合在一起的简明工具具有 96%的特异性(95%置信区间为 94%-99%)和 71%的敏感性(95%置信区间为 66%-77%)。
在不同年龄组合里程碑提供了一种简明的工具,可以帮助在幼儿时期检测出患有 SLI 的儿童。