Gokuladhas K, Sivapriya N, Barath M, NewComer Charles H
World Stem Cell Clinic India LLP (ISO 9001:2015 Certified Clinic), #6, 9th Cross Street, Kapaleeshwar Nagar, Neelankarai, Chennai 600115, India.
Genes Dis. 2017 Feb 10;4(2):88-99. doi: 10.1016/j.gendis.2017.01.002. eCollection 2017 Jun.
The recent emerging field of regenerative medicine is to present solutions for chronic diseases which cannot be sufficiently repaired by the body's own mechanisms. Stem cells are undifferentiated biological cells and have the potential to develop into many different cell types in the body during early life and growth. Self renewal and totipotency are the characteristic features of stem cells and it holds a promising result for treating various diseases like diabetic foot ulcer, heart diseases, lung diseases, Autism, Skin diseases, arthritis including eye disease. Failure of complete recovery of eye diseases and complications that follow conventional treatments have shifted search to a new form of regenerative medicine using Stem cells. The ocular progenitor cells are remarkable in stem cell biology and replenishing degenerated cells despite being present in low quantity and quiescence in our body has a high therapeutic value. In this paper we have review the applications on ocular progenitor stem cells in treatment of human eye diseases and address the strategies that have been exploited in an effort to regain visual function in the advance treatment of stem cells without any side effects and also present the significance in advance stem cell research.
再生医学这一新兴领域旨在为那些无法通过人体自身机制充分修复的慢性疾病提供解决方案。干细胞是未分化的生物细胞，在生命早期和生长过程中具有发育成体内多种不同细胞类型的潜力。自我更新和全能性是干细胞的特征，它在治疗各种疾病方面有着广阔前景，如糖尿病足溃疡、心脏病、肺病、自闭症、皮肤病、关节炎，包括眼病。传统治疗后眼病无法完全恢复以及随之而来的并发症，促使人们将探索方向转向利用干细胞的新型再生医学。眼祖细胞在干细胞生物学中很突出，尽管在我们体内数量稀少且处于静止状态，但补充退化细胞具有很高的治疗价值。在本文中，我们综述了眼祖干细胞在治疗人类眼病中的应用，并探讨了在干细胞先进治疗中为恢复视觉功能所采用的策略，且无任何副作用，同时还阐述了先进干细胞研究的意义。
