Li Shufen, Li Jingming, Chen Chen, Zhang Rongsheng, Wang Kankan
State Key Laboratory of Medical Genomics and Shanghai Institute of Hematology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
McMaster University, Hamilton, Ontario, Canada.
Genes Dis. 2017 Nov 21;5(1):27-35. doi: 10.1016/j.gendis.2017.11.003. eCollection 2018 Mar.
Changes in the abundance and activity of long non-coding RNAs (lncRNAs) have an important impact on the development of cancer. The nuclear paraspeckle assembly transcript 1 (NEAT1) has been reported to be overexpressed in many types of cancer since its discovery. However, inconsistencies exist as NEAT1 can also function as a tumor suppressor in certain types of cancer, such as acute promyelocytic leukemia. Here we systematically describe our current understanding of NEAT1 in tumor initiation and progression. First, we analyzed the expression patterns of NEAT1 in various normal tissues and malignant cancers using data from public data portals, the Genotype-Tissue Expression Project (GTEx) and the Cancer Genome Atlas (TCGA), together with recent progress in the study of NEAT1 in various types of cancer. Second, we discussed the functions and mechanisms of NEAT1 in modulating tumor activity. Then, the upstream transcription factors and downstream microRNA targets of NEAT1 in the transcription cascade of cancers were also summarized. These data highlight the emerging role of NEAT1 in tumorigenesis, and present promising targetable pathways and clinical opportunities for tumor prevention and classifications.
长链非编码RNA（lncRNA）丰度和活性的变化对癌症发展具有重要影响。自发现以来，核旁斑组装转录本1（NEAT1）在多种癌症中均有过表达的报道。然而，也存在不一致的情况，因为NEAT1在某些类型的癌症（如急性早幼粒细胞白血病）中也可发挥肿瘤抑制作用。在此，我们系统地阐述了目前对NEAT1在肿瘤起始和进展过程中的认识。首先，我们利用公共数据平台、基因型-组织表达项目（GTEx）和癌症基因组图谱（TCGA）的数据，以及NEAT1在各类癌症研究中的最新进展，分析了NEAT1在各种正常组织和恶性肿瘤中的表达模式。其次，我们讨论了NEAT1调节肿瘤活性的功能和机制。然后，还总结了NEAT1在癌症转录级联反应中的上游转录因子和下游微小RNA靶点。这些数据凸显了NEAT1在肿瘤发生中的新作用，并为肿瘤预防和分类提供了有前景的可靶向途径和临床机遇。
Zotero 插件
