InfiniumPurify：一个用于在癌症甲基化研究中估计和计算肿瘤纯度的R软件包。
InfiniumPurify: An R package for estimating and accounting for tumor purity in cancer methylation research.
作者信息
Qin Yufang, Feng Hao, Chen Ming, Wu Hao, Zheng Xiaoqi
机构信息
College of Information Technology, Shanghai Ocean University, Shanghai, 201306, PR China.
Key Laboratory of Fisheries Information Ministry of Agriculture, Shanghai, 201306, PR China.
出版信息
Genes Dis. 2018 Feb 21;5(1):43-45. doi: 10.1016/j.gendis.2018.02.003. eCollection 2018 Mar.
The proposition of cancer cells in a tumor sample, named as tumor purity, is an intrinsic factor of tumor samples and has potentially great influence in variety of analyses including differential methylation, subclonal deconvolution and subtype clustering. InfiniumPurify is an integrated R package for estimating and accounting for tumor purity based on DNA methylation Infinium 450 k array data. InfiniumPurify has three main functions getPurity, InfiniumDMC and InfiniumClust, which could infer tumor purity, differential methylation analysis and tumor sample cluster accounting for estimated or user-provided tumor purities, respectively. The InfiniumPurify package provides a comprehensive analysis of tumor purity in cancer methylation research.
肿瘤样本中癌细胞的占比（称为肿瘤纯度）是肿瘤样本的一个内在因素，在包括差异甲基化、亚克隆反卷积和亚型聚类在内的各种分析中可能具有重大影响。InfiniumPurify是一个集成的R包，用于基于DNA甲基化Infinium 450k阵列数据估计和考虑肿瘤纯度。InfiniumPurify有三个主要功能：getPurity、InfiniumDMC和InfiniumClust，它们可以分别推断肿瘤纯度、进行差异甲基化分析以及根据估计的或用户提供的肿瘤纯度对肿瘤样本进行聚类。InfiniumPurify包为癌症甲基化研究中的肿瘤纯度提供了全面的分析。
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