Yasuda Yuzuru
Department of Neurology, Yasuda Clinic, 62-4, Takenokaido-cho, Takeha, Yamasina-ku, Kyoto 607-8080, Japan.
eNeurologicalSci. 2018 Sep 10;13:5-7. doi: 10.1016/j.ensci.2018.09.001. eCollection 2018 Dec.
Pleurothotonus, commonly known as Pisa syndrome (PS), is characterized by abnormal lateral flexion of the trunk. The precise mechanism of this disease is unknown. Istradefylline was administered to a 68-year-old male patient with Parkinson's disease (PD) to treat wearing-off; however, PS appeared 4 months after the first istradefylline treatment. Despite drug adjustments for 9 months, no improvement was observed. Finally, istradefylline was discontinued, and PS symptoms gradually improved over the subsequent 4 months and eventually disappeared. From 2005 to 2014, six studies appeared in the literature on dopaminergic therapy for PS patients with PD. The period between PS appearance after drug introduction until PS recovery with appropriate treatment differs among drugs. This study aimed to identify the drugs that initiate PS and assess the period between PS appearance and disappearance, respectively, after the drug is first administered and later discontinued.
角弓反张，通常称为 Pisa 综合征（PS），其特征为躯干异常侧屈。该病的确切机制尚不清楚。一名 68 岁帕金森病（PD）男性患者接受了依折麦布治疗以应对疗效减退；然而，在首次使用依折麦布治疗 4 个月后出现了 PS。尽管进行了 9 个月的药物调整，但未见改善。最后，停用了依折麦布，PS 症状在随后 4 个月逐渐改善并最终消失。2005 年至 2014 年，文献中出现了 6 项关于多巴胺能疗法治疗 PD 合并 PS 患者的研究。不同药物导致 PS 出现至经适当治疗恢复 PS 的时间间隔有所不同。本研究旨在分别确定引发 PS 的药物，并评估首次用药后及随后停药后 PS 出现至消失的时间间隔。
