Hamm B, Römer T, Felix R, Wolf K J
Rofo. 1986 Dec;145(6):684-91. doi: 10.1055/s-2008-1049016.
The use of the para-magnetic contrast medium gadolinium DTPA for magnetic resonance tomography of focal lesions in the liver was investigated in 31 patients. Two dosage schedules of the contrast medium (0.1 and 0.2 mmol/kg body weight were used with field strengths of 0.35 and 0.5 Tesla. Using T1 sequences, gadolinium DTPA showed increased signal intensity in the liver and in tumours, but this was significantly more marked in the tumour. On T1 spin-echo sequences, previously iso-intense lesions became visible after administration of contrast. On the other hand, contrast-enhanced lesions were less well seen on inversion recovery sequences because of a reduction in the contrast between tumour and liver tissue. The contrast between tumour and liver tissue was not improved by gadolinium DTPA in comparison with precontrast inversion recovery sequences and T2 spin-echo sequences. The perfusion of intra-hepatic tumours could be elucidated by magnetic resonance tomography after the administration of gadolinium DTPA.
对31例患者使用顺磁性造影剂钆喷酸葡胺进行肝脏局灶性病变的磁共振断层扫描研究。造影剂采用两种给药方案（0.1和0.2 mmol/kg体重），磁场强度分别为0.35和0.5特斯拉。使用T1序列时，钆喷酸葡胺使肝脏和肿瘤的信号强度增加，但在肿瘤中更为明显。在T1自旋回波序列上，给药前等信号强度的病变给药后变得可见。另一方面，由于肿瘤与肝组织之间的对比度降低，在反转恢复序列上增强的病变显示不佳。与造影前的反转恢复序列和T2自旋回波序列相比，钆喷酸葡胺并未改善肿瘤与肝组织之间的对比度。钆喷酸葡胺给药后，磁共振断层扫描可阐明肝内肿瘤的灌注情况。
