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钆喷酸葡胺作为磁共振成像中的口服造影剂

[Gadolinium-DTPA as an oral contrast medium in magnetic resonance tomography].

作者信息

Kaminsky S, Laniado M, Gogoll M, Kornmesser W, Clauss W, Felix R

出版信息

Radiol Diagn (Berl). 1989;30(5):541-8.

PMID:2587719
Abstract

80 patients with tumorous or inflammatory abdominal diseases were investigated with the paramagnetic MRT contrast medium Gadolinium-DTPA (Gd-DTPA, 1 mM, 15 g/l mannitol, 6-16 ml per kg body weight) at 0.5 Tesla with T1-, proton density and T2-weighted SE- and gradient-echo sequences. 53 patients were investigated also before the contrast medium was given. Gd-DTPA showed hyperintense labelling of the intestinal loops that was detectable with all excitation sequences and was constant over all phases of the passage. In 35 of the 53 patients investigated before and after application of Gd-DTPA lesions were better imaged while diagnostic improvements, especially for smaller lesions, were achieved in 5 of 80 patients. One third of the patients reported slight meteorism and diarrhoea after the mannitol-containing suspension.

摘要

80例患有肿瘤性或炎性腹部疾病的患者使用顺磁性磁共振成像造影剂钆喷酸葡胺(Gd-DTPA,1 mM,15 g/l甘露醇,每千克体重6 - 16 ml)在0.5特斯拉磁场下,采用T1加权、质子密度加权以及T2加权的自旋回波序列和梯度回波序列进行检查。53例患者在注射造影剂之前也进行了检查。Gd-DTPA使肠袢呈现高信号标记,在所有激发序列中均可检测到,且在通过的所有阶段保持不变。在53例接受Gd-DTPA注射前后检查的患者中,35例的病变成像效果更好,而在80例患者中有5例实现了诊断改善,尤其是对较小病变的诊断。三分之一的患者在服用含甘露醇的悬浮液后出现轻微腹胀和腹泻。

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