1 Neurology Department, Medical School, Heraklion, University of Crete, Crete, Greece.
2 Psychiatry Department, University of Crete, Medical School, Heraklion, Crete, Greece.
Am J Alzheimers Dis Other Demen. 2019 Feb;34(1):23-33. doi: 10.1177/1533317518802414. Epub 2018 Sep 27.
Our aim was to explore the burden of dementia in the Cretan Aging Cohort, comprised of 3140 persons aged ≥60 years (56.8% women, 5.8 ± 3.3 years formal education, 86.2% living in rural areas) who attended selected primary health-care facilities on the island of Crete, Greece. In the first study phase, a formal diagnosis of dementia had been reached in 4.0% of the participants. However, when selected 505 participants underwent thorough neuropsychiatric evaluation in the second phase of this study (344 with Mini-Mental State Examination [MMSE] <24 and 161 with MMSE ≥24), and results were extrapolated to the entire cohort, the prevalence of dementia and mild cognitive impairment was estimated at 10.8% (9.7%-11.9%) and 32.4% (30.8%-34.0%), respectively. Using both the field diagnostic data and the extrapolated data, the highest dementia prevalence (27.2%) was found in the 80- to 84-year-old group, who also showed the lowest educational level, apparently due to lack of schooling during World War II.
我们的目的是探讨克里特老龄化队列中痴呆症的负担，该队列由 3140 名年龄≥60 岁的人组成（56.8%为女性，受教育年限为 5.8±3.3 年，86.2%居住在农村地区），他们参加了希腊克里特岛的选定初级保健机构。在第一研究阶段，4.0%的参与者被正式诊断为痴呆症。然而，当在本研究的第二阶段对 505 名选定的参与者进行了全面的神经精神病学评估（344 名 MMSE＜24，161 名 MMSE≥24），并将结果外推至整个队列时，痴呆症和轻度认知障碍的患病率估计分别为 10.8%（9.7%-11.9%）和 32.4%（30.8%-34.0%）。使用现场诊断数据和外推数据，80-84 岁年龄组的痴呆症患病率最高（27.2%），该组的受教育程度也最低，显然是由于二战期间缺乏学校教育。
