Panagiotakis Symeon H, Simos Panagiotis, Basta Maria, Zaganas Ioannis, Perysinaki Garyfalia S, Akoumianakis Ioannis, Tziraki Chariklia, Lionis Christos, Vgontzas Alexandros, Boumpas Dimitrios
Internal Medicine Department, Heraklion University Hospital, Heraklion, Crete, Greece.
Psychiatry Department, Medical School, University of Crete, Heraklion, Crete, Greece.
Maedica (Bucur). 2022 Mar;17(1):20-27. doi: 10.26574/maedica.2022.17.1.20.
Comprehensive characterization of potential frailty determinants, including sociodemographic, clinical, dietary, psychological, cognitive and systemic inflammation parameters. A rural cohort of 186 subjects aged 60-89 years recruited from a community-based study in Crete, Greece (the Cretan Aging Cohort). Frailty was assessed with the Simple "Frail" Questionnaire Screening Tool. Univariate analyses revealed significant (a) positive associations (p<0.01) between frailty and age, widowhood, Geriatric Depression Scale (GDS) score, waist circumference, polypharmacy, IL-6 and (b) negative associations between frailty and frequency of contact with friends, Mini Mental State Examination (MMSE), and adherence to the Mediterranean diet. Multivariate analyses revealed a significant independent contribution of the following variables to frailty: age (B=0.035, p<0.001), GDS score (B=0.041, p=0.034), polypharmacy (B=0.568, p<0.001), waist circumference (B=0.015, p=0,006), plasma IL-6 levels (B=0.189, p=0.004), and adherence to the Mediterranean diet (B=-0.036, p=0.015). Older age, depression symptoms, polypharmacy, waist circumference, poor adherence to Mediterranean diet and IL-6 plasma levels are associated with increased frailty.
对潜在的衰弱决定因素进行全面表征，包括社会人口统计学、临床、饮食、心理、认知和全身炎症参数。从希腊克里特岛一项基于社区的研究（克里特岛老龄化队列）中招募了186名年龄在60 - 89岁的农村受试者。使用简易“衰弱”问卷筛查工具评估衰弱情况。单因素分析显示：（a）衰弱与年龄、丧偶、老年抑郁量表（GDS）评分、腰围、多种药物治疗、白细胞介素-6之间存在显著正相关（p<0.01）；（b）衰弱与与朋友的联系频率、简易精神状态检查表（MMSE）以及坚持地中海饮食之间存在负相关。多因素分析显示以下变量对衰弱有显著的独立影响：年龄（B = 0.035，p<0.001）、GDS评分（B = 0.041，p = 0.034）、多种药物治疗（B = 0.568，p<0.001）、腰围（B = 0.015，p = 0.006）、血浆白细胞介素-6水平（B = 0.189，p = 0.004）以及坚持地中海饮食（B = -0.036，p = 0.015）。年龄较大、抑郁症状、多种药物治疗、腰围、对地中海饮食的依从性差以及血浆白细胞介素-6水平与衰弱增加有关。
