三氧化二砷优先与 PML 环指蛋白结合：了解药物的靶标选择。
Arsenic trioxide preferentially binds to the ring finger protein PML: understanding target selection of the drug.
机构信息
CAS Key Laboratory of Soft Matter Chemistry, CAS High Magnetic Field Laboratory, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China.
出版信息
Metallomics. 2018 Nov 14;10(11):1564-1569. doi: 10.1039/c8mt00202a.
Arsenic trioxide (ATO) is used in the clinic for the treatment of acute promyelocytic leukemia by targeting the protein PML. However, many zinc-finger proteins could also be reactive to arsenic in cells. Here we found that ATO preferentially binds to the ring-finger domain of PML in a protein mixture with zinc-finger domains. These results provide the molecular basis of the target selection of ATO in cells.
三氧化二砷（ATO）通过靶向蛋白 PML 用于治疗急性早幼粒细胞白血病。然而，许多锌指蛋白在细胞中也可能对砷有反应。在这里，我们发现 ATO 在含有锌指结构域的蛋白质混合物中优先与 PML 的环指结构域结合。这些结果为 ATO 在细胞中的靶标选择提供了分子基础。
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