Department of Biotechnology, Institute of Graduate studies and Research, Alexandria University, Alexandria 21526, Egypt.
Department of Chemistry of Natural and Microbial Products, Pharmaceutical and Drug Industries Research Division, National Research Centre, 33 El-Behooth St, Dokki, Giza 12311, Egypt.
Int J Biol Macromol. 2020 Dec 1;164:1046-1060. doi: 10.1016/j.ijbiomac.2020.07.167. Epub 2020 Jul 22.
Lactoferrin (LF) is a naturally glycoprotein with iron-binding properties and diverse biological applications including; antiviral, anti-inflammatory, antioxidant, anti-cancer and immune stimulating effects. In addition, LF was found to be an ideal nanocarrier for some hydrophobic therapeutics because of its active targeting potential due to overexpression of its receptor on the surface of many cells. Moreover, it was proven to be a good candidate for fabrication of nanocarriers to specifically deliver drugs in case of brain tumors owing to the capability of LF to cross the blood brain barrier (BBB). Consequently, it seems to be a promising molecule with multiple applications in the field of cancer therapy and nanomedicine.
乳铁蛋白（LF）是一种天然糖蛋白，具有铁结合特性和多种生物学应用，包括抗病毒、抗炎、抗氧化、抗癌和免疫刺激作用。此外，由于其受体在许多细胞表面过度表达，LF 被发现是一些疏水性治疗药物的理想纳米载体，因为它具有主动靶向的潜力。此外，由于 LF 能够穿透血脑屏障（BBB），因此它被证明是一种用于制造纳米载体以专门递送到脑肿瘤的药物的良好候选物。因此，它似乎是一种具有多种应用的有前途的分子，可应用于癌症治疗和纳米医学领域。
