[α和γ干扰素制剂中的白细胞迁移抑制因子]
[Leukocyte migration inhibiting factor in preparations of alpha and gamma interferons].
作者信息
Vakhromeeva N S, Bagaeva L V, Kuznetsov V P, Medunitsyn N V, Bobkova E V
出版信息
Vopr Virusol. 1986 Sep-Oct;31(5):617-9.
PMID:3026096
Abstract
High titres of leukocyte migration inhibition factor (LMIF) activity were found in native and partially purified preparations of human alpha- and gamma-interferon. In the course of chemical purification of interferon up to 98% of LMIF was lost. The highest content of LMIF was in gamma-interferon preparations, while recombinant alpha 2-interferon (reaferon) showed no LMIF activity.
摘要
在人α-干扰素和γ-干扰素的天然及部分纯化制剂中发现了高滴度的白细胞迁移抑制因子（LMIF）活性。在干扰素的化学纯化过程中，高达98%的LMIF活性丧失。LMIF含量最高的是γ-干扰素制剂，而重组α2-干扰素（利芬能）则无LMIF活性。
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