低壁切应力与高分辨率磁共振血管壁成像上的局部动脉瘤壁增强有关。
Low Wall Shear Stress Is Associated with Local Aneurysm Wall Enhancement on High-Resolution MR Vessel Wall Imaging.
机构信息
From the Departments of Neurosurgery (W.X.,T.Q., S.O., G.Z., X.L., Z.H., F.L.).
Radiology (S.H., Z.L.), The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
出版信息
AJNR Am J Neuroradiol. 2018 Nov;39(11):2082-2087. doi: 10.3174/ajnr.A5806. Epub 2018 Sep 27.
BACKGROUND AND PURPOSE
Some retrospective studies have found that the aneurysm wall enhancement on high-resolution MR vessel wall postgadolinium T1WI has the potential to distinguish unstable aneurysms. This study aimed to identify hemodynamic characteristics that differ between the enhanced and nonenhanced areas of the aneurysm wall on high-resolution MR vessel wall postgadolinium T1WI.
MATERIALS AND METHODS
TOF-MRA and high-resolution MR vessel wall T1WI of 25 patients were fused to localize the enhanced area of the aneurysm wall. Using computational fluid dynamics, we studied the aneurysm models. Mean static pressure, mean wall shear stress, and oscillatory shear index were compared between the enhanced and nonenhanced areas.
RESULTS
The aneurysmal enhanced area had lower wall shear stress ( < .05) and a lower oscillatory shear index ( = .021) than the nonenhanced area. In addition, the whole aneurysm had lower wall shear stress ( < .05) and a higher oscillatory shear index ( = .007) than the parent artery.
CONCLUSIONS
This study suggests that there are hemodynamic differences between the enhanced and nonenhanced areas of the aneurysm wall on high-resolution MR vessel wall postgadolinium T1WI.
背景与目的
一些回顾性研究发现，高分辨率磁共振血管壁成像钆对比增强 T1WI 上的动脉瘤壁强化有潜力区分不稳定的动脉瘤。本研究旨在确定高分辨率磁共振血管壁成像钆对比增强 T1WI 上动脉瘤壁强化与非强化区域之间存在差异的血流动力学特征。
材料与方法
将 25 例患者的时间飞跃磁共振血管造影和高分辨率磁共振血管壁 T1WI 融合，以定位动脉瘤壁的强化区域。使用计算流体动力学，我们研究了动脉瘤模型。比较强化区和非强化区的平均静压、平均壁面切应力和振荡剪切指数。
结果
动脉瘤的强化区壁面切应力较低（<0.05），振荡剪切指数较低（=0.021）。此外，整个动脉瘤的壁面切应力较低（<0.05），振荡剪切指数较高（=0.007）。
结论
本研究表明，高分辨率磁共振血管壁成像钆对比增强 T1WI 上动脉瘤壁强化区与非强化区之间存在血流动力学差异。
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