Shimbo Genya, Tagawa Michihito, Yanagawa Masashi, Miyahara Kazuro
Veterinary Medical Center, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan.
Current address: Veterinary Teaching Hospital, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.
JFMS Open Rep. 2018 Sep 20;4(2):2055116918801602. doi: 10.1177/2055116918801602. eCollection 2018 Jul-Dec.
A 2-year-old neutered female domestic shorthair cat presented with a history of hypodipsia, recurrent hypernatraemia, pelvic limb ataxia and tremor. The serum arginine vasopressin level was low for the serum osmolality. MRI of the brain revealed a failure of separation of the cerebrum, which manifested as absence of the rostral part of the corpus callosum, fornix and septum pellucidum, thus resulting in a single fused ventricle. The diagnosis was lobar holoprosencephaly with hypodipsic hypernatraemia.
To our knowledge, this is the first description of the MRI characteristics of lobar holoprosencephaly in a cat. This report suggests that MRI examination should be considered for precise diagnosis of hypodipsic hypernatraemia in young cats.
一只2岁已绝育的雌性家养短毛猫，有饮水过少、反复高钠血症、后肢共济失调和震颤的病史。血清渗透压下血清精氨酸加压素水平较低。脑部MRI显示大脑分离失败，表现为胼胝体、穹窿和透明隔前部缺失，从而导致单一融合脑室。诊断为叶状全前脑畸形伴饮水过少性高钠血症。
据我们所知，这是猫叶状全前脑畸形MRI特征的首次描述。本报告表明，对于幼猫饮水过少性高钠血症的精确诊断，应考虑进行MRI检查。
