Canada West Veterinary Specialists, Vancouver, British Columbia, Canada.
Department of Clinical Veterinary Sciences, University of Bern, Bern, Switzerland.
J Vet Intern Med. 2020 Nov;34(6):2682-2686. doi: 10.1111/jvim.15907. Epub 2020 Oct 3.
A 10-month-old neutered male mixed breed dog was presented for assessment of poorly controlled seizures.
Magnetic resonance imaging of the brain disclosed complete absence of the lateral and third ventricles and mesencephalic aqueduct. Postmortem computed tomographic (CT) imaging and positive contrast cisterno-ventriculography confirmed the lack of a contiguous ventricular system. However, histopathology identified the presence of vestigial lateral and third ventricles with hypoplastic choroid plexus, atresia of the third ventricle, and fused thalami, consistent with a diagnosis of lobar holoprosencephaly (HPE).
To our knowledge, this report is the first case of radiographically confirmed aventriculi associated with HPE, a rare congenital malformation previously reported in people, to be described in veterinary medicine.
一只 10 月龄已去势的雄性混血犬因癫痫发作难以控制就诊。
脑部磁共振成像显示侧脑室和第三脑室完全缺失，中脑导水管狭窄。尸检计算机断层扫描（CT）和阳性对比脑室造影证实脑室系统不连续。然而，组织病理学检查发现，存在残留的侧脑室和第三脑室，脉络丛发育不良，第三脑室狭窄，丘脑融合，符合脑裂畸形（HPE）的诊断。
据我们所知，本报告是首例影像学证实的无脑畸形合并 HPE 的病例，此前在人类中已有报道，在兽医领域尚属首例。
