Korkmaz Sevda, Üstündağ Bilal, Özer Ömer, Taşç Gülay, Kaya Şüheda, Ateşçelik Metin, Atmaca Murad
Department of Psychiatry, Fırat University Medicine Faculty, Turkey.
Department of Biochemistry, Fırat University Medicine Faculty, Turkey.
S Afr J Psychiatr. 2016 Oct 24;22(1):976. doi: 10.4102/sajpsychiatry.v22i1.976. eCollection 2016.
Self-mutilation, known as self-harming behaviour of an individual without the intention of suicide, is commonly observed in individuals with borderline personality disorder. The objective of this study is to compare copeptin levels that are known to be related to aggressive behaviour and blood lipid profiles in borderline patients with and without self-mutilation.
Twenty patients with self-mutilation [SM(+)] and 20 patients without self-mutilation [SM(-)] between the ages of 18 and 49, diagnosed with borderline personality disorder based on DSM-IV-TR(8) diagnostic criteria and attended to by Fırat University Psychiatry Polyclinic, participated in the study. Socio-demographic and clinical data form, Hamilton Depression Rating Scale, Hamilton Anxiety Rating Scale (HAMA) and Barrat Impulsivity Scale (BIS) were applied to all participants. Copeptin levels and plasma lipid levels were studied in the blood samples taken from the participants.
Mean copeptin level found in SM(+) group (37.54 ± 18.8 ng/mL) was statistically significantly higher than SM(-) group (18.53 ± 16.6 ng/mL) ( = 0.002). A negative correlation was found between mean copeptin and mean total cholesterol levels ( = -0.436; = 0.005), and between copeptin and low-density lipoprotein cholesterol (LDL) levels ( = -0.403; = 0.01) in both SM(+) and SM(-) patient groups. HAMA mean score for SM(+) group was found as 36.45 ± 13.2, and for SM(-) group, it was found as 35.7 ± 12.9. There was a statistically significant difference between the depression points achieved by the two groups ( = 0.046). BIS total points average for SM(+) group was determined as 71 ± 9.71, whereas it was determined as 66.8 ± 7.92 in SM(-) group. There was no statistically significant difference between the groups based on anxiety points. Barrat planning, Barrat motor and Barrat attention points for SM(+) group were higher than the SM(-) group. However, the difference was not statistically significant ( > 0.05).
Findings of the study demonstrated that as cholesterol and LDL levels decreased, copeptin levels increased, and that could be related to the self-mutilation behaviour.
自我伤害行为，即个体无自杀意图的自我伤害行为，在边缘型人格障碍患者中较为常见。本研究的目的是比较已知与攻击行为相关的 copeptin 水平以及有和无自我伤害行为的边缘型患者的血脂谱。
20 名有自我伤害行为的患者[SM(+)]和 20 名无自我伤害行为的患者[SM(-)]，年龄在 18 至 49 岁之间，根据 DSM-IV-TR(8)诊断标准被诊断为边缘型人格障碍，并在菲拉特大学精神病学门诊接受治疗，参与了本研究。对所有参与者应用社会人口统计学和临床数据表格、汉密尔顿抑郁评定量表、汉密尔顿焦虑评定量表（HAMA）和巴拉特冲动量表（BIS）。对参与者采集的血样进行 copeptin 水平和血脂水平研究。
SM(+)组的平均 copeptin 水平（37.54±18.8 ng/mL）在统计学上显著高于 SM(-)组（18.53±16.6 ng/mL）（P = 0.002）。在 SM(+)和 SM(-)患者组中，平均 copeptin 与平均总胆固醇水平之间均发现负相关（r = -0.436；P = 0.005），以及 copeptin 与低密度脂蛋白胆固醇（LDL）水平之间负相关（r = -0.403；P = 0.01）。SM(+)组的 HAMA 平均得分为 36.45±13.2，SM(-)组为 35.7±12.9。两组的抑郁得分存在统计学显著差异（P = 0.046）。SM(+)组的 BIS 总分平均值确定为 71±9.71，而 SM(-)组为 66.8±7.92。基于焦虑得分，两组之间无统计学显著差异。SM(+)组的巴拉特计划性、巴拉特运动性和巴拉特注意力得分高于 SM(-)组。然而，差异无统计学显著性（P>0.05）。
研究结果表明，随着胆固醇和 LDL 水平降低，copeptin 水平升高，这可能与自我伤害行为有关。
