高良姜素在HCT-116细胞中的分子结构及抗增殖作用：研究
Molecular structure and anti-proliferative effect of galangin in HCT-116 cells: study.
作者信息
Sulaiman Ghassan Mohammad
机构信息
Biotechnology Division, Applied Science Department, University of Technology, Baghdad, Iraq.
出版信息
Food Sci Biotechnol. 2016 Feb 29;25(1):247-252. doi: 10.1007/s10068-016-0036-4. eCollection 2016.
Abstract
Galangin is a naturally occurring plant flavonoid with potential anticancer activity. In present work, the Becke three-parameter hybrid exchange functional method and the Lee-Yang-Parr correction functional methods were used to investigate the structural properties of galangin. The structure-activity relationship analysis has been performed to determine its antioxidant pharmacophore by using density functional theory method and quantum chemical calculations. The free radical scavenging activities of galangin were analyzed with the use of 2, 2-diphenyl-1-picrylhydrazyl and compared with Vitamin C as a control. Galangin decreased the cell proliferation rate in HCT-116 cells and showed concentration- and time-dependent response. Galangin significantly increase the inhibitory effect on HCT-116 clonogenicity and promotes cell cycle arrest at the G2/M or G1 phase, as confirmed by flow cytometry analysis.
摘要
高良姜素是一种具有潜在抗癌活性的天然植物黄酮类化合物。在本研究中，采用Becke三参数混合交换泛函方法和Lee-Yang-Parr校正泛函方法研究了高良姜素的结构性质。利用密度泛函理论方法和量子化学计算进行了构效关系分析，以确定其抗氧化药效团。使用2,2-二苯基-1-苦基肼分析了高良姜素的自由基清除活性，并与作为对照的维生素C进行了比较。高良姜素降低了HCT-116细胞的增殖率，并表现出浓度和时间依赖性反应。流式细胞术分析证实，高良姜素显著增强了对HCT-116克隆形成能力的抑制作用，并促进细胞周期停滞在G2/M期或G1期。
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