生理浓度的-11 18:1 反式vaccenic酸可抑制急性炎症状态下分离的ICR小鼠脾细胞中的促炎标志物。
Physiological concentrations of -11 18:1 vaccenic acid suppress pro-inflammatory markers under acute inflammation in isolated ICR mice splenocytes.
作者信息
Lee Jae-Sung, Lim Ji-Na, Wang Tao, Lee Sang-Bum, Hwang Jin-Hee, Jung U-Suk, Kim Min-Jeong, Choi Seong-Ho, Ishizuka Satoshi, Lee Hong-Gu
机构信息
1Department of Animal Science and Technology, College of Animal Bioscience & Technology, Konkuk University, Seoul, 05029 Korea.
2College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130118 China.
出版信息
Food Sci Biotechnol. 2016 Feb 29;25(1):275-281. doi: 10.1007/s10068-016-0040-8. eCollection 2016.
Direct influences of dietary -11 18:1 vaccenic acid (TVA) at physiological concentrations of 50-200 μM were evaluated for cell growth, cytotoxic activity, and cytokine production in leukocytes isolated from the mouse spleen. TVA supplementation for 24 h induced growth of splenocytes at concentrations of 50-200 μM, except for 100 μM. The cytokines TNFα, IFNγ, and IL-10 of splenocytes were stimulated by 100 μM TVA. Induced production of TNFα in splenocytes challenged with lipopolisaccharides was suppressed by 100 μM TVA. Physiological levels of TVA had direct effects on growth and cytokine production in splenocytes. Further studies are needed to improve understanding of the precise influence of fatty acids on production of pro-inflammatory markers under acute inflammation conditions.
在从小鼠脾脏分离的白细胞中，评估了生理浓度为50-200μM的膳食反式-11 18:1 vaccenic酸（TVA）对细胞生长、细胞毒性活性和细胞因子产生的直接影响。除100μM外，24小时补充TVA可在50-200μM浓度下诱导脾细胞生长。100μM TVA刺激脾细胞的细胞因子TNFα、IFNγ和IL-10。100μM TVA抑制了用脂多糖攻击的脾细胞中TNFα的诱导产生。TVA的生理水平对脾细胞的生长和细胞因子产生有直接影响。需要进一步研究以更好地理解脂肪酸在急性炎症条件下对促炎标志物产生的精确影响。
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