Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Brain and Mind Institute, Ecole Polytechnique Féderale de Lausanne EPFL, Lausanne, Switzerland.
Brain Struct Funct. 2019 Jan;224(1):1-8. doi: 10.1007/s00429-018-1759-1. Epub 2018 Sep 27.
The identification and reconstruction of axonal pathways in the living brain or "ex-vivo" is promising a revolution in connectivity studies bridging the gap from animal to human neuroanatomy with extensions to brain structural-functional correlates. Unfortunately, the methods suffer from juvenile drawbacks. In this perspective paper we mention several computational and developmental principles, which might stimulate a new generation of algorithms and a discussion bridging the neuroimaging and neuroanatomy communities.
在活体大脑或“离体”中识别和重建轴突通路有望带来一场连接研究的革命，弥合从动物神经解剖学到人类神经解剖学的差距，并扩展到大脑结构-功能相关性。不幸的是，这些方法存在一些不成熟的缺陷。在本文中，我们提到了一些计算和发展原则，这些原则可能会激发新一代算法的产生，并在神经影像学和神经解剖学领域之间展开讨论。
