Li Jinfeng, Deng Changkai, Peng Qiang
Department of Pediatric Surgery, Chengdu Women's and Children's Central Hospital of Chongqing Medical University, No.1617, Riyue avenue, Qinyang District, Chengdu, China.
Pediatr Surg Int. 2018 Nov;34(11):1245-1250. doi: 10.1007/s00383-018-4357-7. Epub 2018 Sep 27.
Previous histological studies have shown a variable incidence of genital lichen sclerosus (LS). However, the results of these studies were inconsistent. To overcome the limitation of individual studies, we performed this systematic review to explore the true incidence of LS.
A comprehensive search of Pubmed, Embase, Web of Science and Cochrane Library was performed including cross-referencing independently by two assessors.
A total of 22 articles published from 1980 to 2017 were included in our study. The proportion of LS in those with phimosis had been described in many literature studies, ranging from 2 to 95%. The actual incidence of LS is thought to be clinically underestimated by as much as 50%.
The true incidence of LS in boys is more common than previously realized. LS may be observed in foreskin with or without phimosis. The presence of acquired phimosis may be an aggravating factor in the incidence of LS. The diagnosis LS must be based on biopsy for acquired phimosis because clinical findings underestimated the incidence of LS.
以往的组织学研究显示，生殖器硬化性苔藓（LS）的发病率存在差异。然而，这些研究结果并不一致。为克服个别研究的局限性，我们进行了这项系统评价，以探究LS的真实发病率。
对PubMed、Embase、科学网和考克兰图书馆进行全面检索，包括由两名评估人员独立进行交叉引用。
我们的研究共纳入了1980年至2017年发表的22篇文章。许多文献研究描述了包茎患者中LS的比例，范围从2%到95%。LS的实际发病率在临床上被认为低估了多达50%。
男孩中LS的真实发病率比之前认为的更为常见。LS可在有或无包茎的包皮中观察到。后天性包茎的存在可能是LS发病率的一个加重因素。对于后天性包茎，LS的诊断必须基于活检，因为临床发现低估了LS的发病率。
