重氮化合物与亚砜叶立德的催化交叉烯化反应

A Catalytic Cross-Olefination of Diazo Compounds with Sulfoxonium Ylides.

作者信息

Neuhaus James D, Bauer Adriano, Pinto Alexandre, Maulide Nuno

机构信息

Institute of Organic Chemistry, University of Vienna, Währinger Straße 38, 1090, Vienna, Austria.

出版信息

Angew Chem Int Ed Engl. 2018 Dec 3;57(49):16215-16218. doi: 10.1002/anie.201809934. Epub 2018 Nov 8.

DOI:10.1002/anie.201809934

PMID:30264529

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6283242/

Abstract

A ruthenium-catalysed cross-olefination of diazo compounds and sulfoxonium ylides is presented. Our reaction design exploits the intrinsic difference in reactivity of diazo compounds and sulfoxonium ylides as both carbene precursors and nucleophiles, which results in a highly selective reaction.

摘要

本文报道了一种钌催化的重氮化合物与亚砜叶立德的交叉烯化反应。我们的反应设计利用了重氮化合物和亚砜叶立德作为卡宾前体和亲核试剂在反应活性上的内在差异，从而实现了高选择性反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a54f/6283242/e9744852b479/ANIE-57-16215-g001.jpg

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重氮化合物与亚砜叶立德的催化交叉烯化反应

A Catalytic Cross-Olefination of Diazo Compounds with Sulfoxonium Ylides.

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重氮化合物与亚砜叶立德的催化交叉烯化反应

A Catalytic Cross-Olefination of Diazo Compounds with Sulfoxonium Ylides.

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