通过级联C-H官能团化/环化反应实现钌催化的吡咯并[1,2-a]吲哚的一锅法区域和非对映选择性合成。
Ruthenium-catalysed one-pot regio- and diastereoselective synthesis of pyrrolo[1,2-a]indoles via cascade C-H functionalization/annulation.
作者信息
Singh Sukhdev, Butani Himanshu H, Vachhani Dipak D, Shah Anamik, Van der Eycken Erik V
机构信息
Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, B-3001, Leuven, Belgium.
出版信息
Chem Commun (Camb). 2017 Sep 28;53(78):10812-10815. doi: 10.1039/c7cc06276a.
A cascade approach has been developed towards dual C-C bond formation via consecutive C-H functionalization/cyclization giving access to pyrrolo[1,2-a]indoles in a highly regio- and diastereoselective manner using catalytic [Ru(p-cymene)Cl]. The methodology was further expanded to attain pentacyclic structures involving manifold C-C bond creation.
通过连续的C-H官能团化/环化反应形成双C-C键的级联方法已经开发出来，该方法使用催化量的[Ru(p-异丙基苯)Cl]，以高度区域和非对映选择性的方式合成吡咯并[1,2-a]吲哚。该方法进一步扩展以获得涉及多个C-C键形成的五环结构。
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