a Programa de Pós-Graduação em Ciência e Tecnologia dos Alimentos , Universidade Federal de Santa Maria , Santa Maria , Rio Grande do Sul , Brasil.
b Programa de Pós-Graduação em Farmacologia , Universidade Federal de Santa Maria , Santa Maria , Rio Grande do Sul , Brasil.
J Environ Sci Health B. 2018;53(12):840-845. doi: 10.1080/03601234.2018.1505258. Epub 2018 Sep 28.
Fu monisin B (FB) is a mycotoxin commonly found in maize and maize-based products. Ingestion of FB-contaminated causes a myriad of dose- and species-dependent toxic effects to human and animal health. In the present study we evaluated the effects of FB (8 mg/kg, i.p. for 4 days) on body weight and oxidative stress parameters in the liver, kidney and lung of C57BL/6 male mice. No changes in the organ-to-body weight ratio, organ-to-adrenal gland weight ratio or organ-to-brain weight ratio were found. On the other hand, FB exposure increased NPSH levels in liver and lungs whereas decreased FRAP content in liver and kidneys. Levels of TBARS, ascorbic acid and NOx content were not altered by FB. In summary, four days of FB exposure are sufficient to disrupt antioxidant defenses in liver, kidneys and lungs of C57BL/6 male mice without concomitant changes in organs weight.
伏马菌素 B（FB）是一种常见于玉米及其制品中的真菌毒素。摄入 FB 污染的物质会对人类和动物的健康产生一系列剂量和物种依赖性的毒性作用。在本研究中，我们评估了 FB（腹腔注射 8mg/kg，连续 4 天）对 C57BL/6 雄性小鼠体重和肝脏、肾脏和肺部氧化应激参数的影响。未发现器官与体重比、器官与肾上腺重量比或器官与脑重量比发生变化。另一方面，FB 暴露增加了肝脏和肺部的 NPSH 水平，而降低了肝脏和肾脏的 FRAP 含量。TBARS、抗坏血酸和 NOx 含量没有因 FB 而改变。综上所述，FB 暴露 4 天足以破坏 C57BL/6 雄性小鼠肝脏、肾脏和肺部的抗氧化防御系统，而器官重量没有同时发生变化。
