Bondy G S, Suzuki C A, Fernie S M, Armstrong C L, Hierlihy S L, Savard M E, Barker M G
Toxicology Research Division, Food Directorate, Health Canada, Ottawa, Canada.
Food Chem Toxicol. 1997 Oct-Nov;35(10-11):981-9. doi: 10.1016/s0278-6915(97)87267-5.
Fumonisin B1 (FB1) is a fungal toxin produced by members of the genus Fusarium. Ingestion of FB1 causes species-specific neurotoxic, nephrotoxic, hepatotoxic and pulmonary effects. The clinical, haematological and pathological responses of adult male and female B6C3F1 mice to FB1 were assessed following 14 daily gavage doses ranging from 1 to 75 mg FB1/kg body weight/day. There were no consistent sex-related changes. Although all responses were modest, the most notable effects of FB1 were on the liver, bone marrow, adrenals and kidneys. In the liver, hepatocellular single cell necrosis, mitosis and anisokaryosis were observed, accompanied by elevated serum ALT. In the kidneys, minor histopathological changes were confined to female mice, while mild decreases in ion transport and increases in blood urea nitrogen were seen only in males. Small changes in glutathione levels were observed in the kidneys and livers of male mice. Adrenal cortical cell vacuolation was observed at 15 mg FB1/kg and higher in females and from 35 mg FB1/kg in males. Serum cholesterol was elevated in both male and female mice, possibly due to FB1-induced changes in lipid metabolism in the liver and adrenals. Although bone marrow cell numbers were unchanged, increases in vacuolated myeloid cells and lymphocytes were observed in female mice. In general, the degree of changes observed indicate that mice are not as sensitive a model of FB1 toxicity as rats.
伏马菌素B1（FB1）是一种由镰刀菌属成员产生的真菌毒素。摄入FB1会导致特定物种出现神经毒性、肾毒性、肝毒性和肺部效应。在对成年雄性和雌性B6C3F1小鼠连续14天经口灌胃给予剂量范围为1至75毫克FB1/千克体重/天的FB1后，评估了其临床、血液学和病理学反应。未发现一致的性别相关变化。尽管所有反应都不明显，但FB1最显著的影响是对肝脏、骨髓、肾上腺和肾脏。在肝脏中，观察到肝细胞单细胞坏死、有丝分裂和核大小不均，同时血清谷丙转氨酶升高。在肾脏中，轻微的组织病理学变化仅限于雌性小鼠，而离子转运轻度下降和血尿素氮升高仅在雄性小鼠中出现。在雄性小鼠的肾脏和肝脏中观察到谷胱甘肽水平有微小变化。在雌性小鼠中，15毫克FB1/千克及以上剂量时观察到肾上腺皮质细胞空泡化，在雄性小鼠中从35毫克FB1/千克剂量开始出现。雄性和雌性小鼠的血清胆固醇均升高，这可能是由于FB1诱导肝脏和肾上腺脂质代谢发生变化所致。尽管骨髓细胞数量未变，但在雌性小鼠中观察到空泡化髓样细胞和淋巴细胞增加。总体而言，观察到的变化程度表明，小鼠作为FB1毒性模型不如大鼠敏感。
