Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands.
Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands.
Environ Int. 2018 Dec;121(Pt 1):435-442. doi: 10.1016/j.envint.2018.09.029. Epub 2018 Sep 25.
It has been suggested that children who are exposed to agricultural pesticides have an increased risk of asthma, but evidence for associations betweeen residential pesticide exposure and childhood asthma is inconsistent.
To investigate the associations of residential pesticide exposure with the prevalence of asthma and related symptoms within a Dutch birth cohort study.
In this cross-sectional analysis, we included participants of the PIAMA birth cohort study with data on residential pesticide exposure and asthma from parent-completed questionnaires at age 14, collected in 2012 (N = 1473). We used spatial data on the presence of individual crops (cereals, open field vegetables, commercial crops, open field floriculture/bulbs, corn and potatoes) and pesticide application on these crops to estimate residential exposure to pesticides with known irritant properties for the respiratory system within distances of 100, 500, and 1000 m of the participants' homes. Logistic regression was used to estimate associations between exposure and outcomes, adjusting for potential confounders.
No associations were found between living within 100, 500 and 1000 m of agricultural fields likely treated with pesticides and symptoms of asthma. For instance, for participants living within 100 m of fields with any crops likely treated with pesticides, the adjusted odds ratios (95% confidence interval) for the prevalence of asthma, shortness of breath and dry night cough at age 14 were 0.31 (0.07, 1.32), 0.61 (0.23, 1.57) and 1.26 (0.56, 2.80), respectively. No associations were found between estimated exposure to pesticides with known irritant properties for the respiratory system and asthma or related symptoms.
There was no association between living near agricultural fields likely treated with pesticides and asthma and related respiratory symptoms, among our study participants.
有研究表明，接触农用杀虫剂的儿童罹患哮喘的风险增加，但居住环境中杀虫剂暴露与儿童哮喘之间的关联证据并不一致。
在一项荷兰出生队列研究中，调查居住环境中杀虫剂暴露与儿童哮喘及相关症状的患病率之间的关联。
在这项横断面分析中，我们纳入了 PIAMA 出生队列研究的参与者，这些参与者在 2012 年完成了父母调查问卷，提供了居住环境中杀虫剂暴露和哮喘的相关数据（n=1473）。我们使用关于单个作物（谷物、露天蔬菜、商业作物、露天花卉/鳞茎、玉米和土豆）存在情况的空间数据，以及这些作物上使用杀虫剂的相关数据，来估算参与者住宅周围 100、500 和 1000 米范围内已知对呼吸系统有刺激性的杀虫剂的暴露程度。使用逻辑回归来估算暴露与结局之间的关联，并对潜在混杂因素进行调整。
我们未发现居住在距离可能使用杀虫剂处理的农业用地 100、500 和 1000 米范围内与哮喘症状之间存在关联。例如，对于居住在距离可能使用任何作物处理的农药的田地 100 米范围内的参与者，14 岁时哮喘、呼吸急促和夜间干咳的患病率的校正比值比（95%置信区间）分别为 0.31（0.07，1.32）、0.61（0.23，1.57）和 1.26（0.56，2.80）。我们也未发现估计的对呼吸系统有刺激性的已知农药暴露与哮喘或相关症状之间存在关联。
在我们的研究参与者中，居住在可能使用农药处理的农业用地附近与哮喘和相关呼吸道症状之间没有关联。
