Department of Pediatric Gastroenterology and Hepatology, University of Pittsburgh School of Medicine, Children's Hospital of Pittsburgh, 4401 Penn Avenue, Pittsburgh, PA 15224, USA.
Department of Pediatric Gastroenterology and Hepatology, University of Pittsburgh School of Medicine, Children's Hospital of Pittsburgh, 4401 Penn Avenue, Pittsburgh, PA 15224, USA.
Clin Liver Dis. 2018 Nov;22(4):773-805. doi: 10.1016/j.cld.2018.06.009. Epub 2018 Aug 22.
Pediatric acute liver failure (PALF) is a dynamic, life-threatening condition of disparate etiology. Management of PALF is dependent on intensive collaborative clinical care and support. Proper recognition and treatment of common complications of liver failure are critical to optimizing outcomes. In parallel, investigations to identify underlying cause and the implementation of timely, appropriate treatment can be life-saving. Predicting patient outcome in the era of liver transplantation has been unfulfilling and better predictive models must be developed for proper stewardship of the limited resource of organ availability.
儿科急性肝衰竭（PALF）是一种病因不同、危及生命的动态疾病。PALF 的管理依赖于强化的协作临床护理和支持。正确识别和治疗肝衰竭的常见并发症对于优化结局至关重要。与此同时，为了确定潜在病因并及时、适当地进行治疗，调查也至关重要，因为这可以挽救生命。在肝移植时代，预测患者的预后一直不尽如人意，必须开发更好的预测模型，以合理管理器官可用性这一有限资源。
