State Key Laboratory of Luminescent Materials & Devices, College of Materials Science & Engineering, South China University of Technology, Guangzhou, 510640, China.
Nat Commun. 2018 Sep 28;9(1):3983. doi: 10.1038/s41467-018-06499-1.
Optoacoustic tomography (photoacoustic tomography) is an emerging imaging technology displaying great potential for medical diagnosis and preclinical research. Rationally designing activatable optoacoustic probes capable of diagnosing diseases and locating their foci can bring into full play the role of optoacoustic tomography (OAT) as a promising noninvasive imaging modality. Here we report two xanthene-based optoacoustic probes (CX-OR and CX-OR) for temporospatial imaging of hepatic alkaline phosphatase (or β-galactosidase) for evaluating and locating drug-induced liver injury (or metastatic tumor). The probes rapidly respond to the disease-specific biomarkers by displaying red-shifted NIR absorption bands and generate prominent optoacoustic signals. Using multispectral optoacoustic tomography (MSOT), we can precisely localize the focus of drug-induced liver injury in mice using CX-OR, and the metastatic tumors using CX-OR. This work suggests that the activatable optoacoustic chromophores may potentially be applied for diagnosing and localizing disease foci, especially smaller and deeper ones.
光声断层扫描（photoacoustic tomography）是一种新兴的成像技术，在医学诊断和临床前研究中具有巨大的应用潜力。合理设计能够诊断疾病并定位病灶的激活型光声探针，可以充分发挥光声断层扫描（OAT）作为一种很有前途的非侵入性成像方式的作用。在这里，我们报告了两种基于呫吨的光声探针（CX-OR 和 CX-OR），用于肝碱性磷酸酶（或β-半乳糖苷酶）的时空成像，以评估和定位药物诱导的肝损伤（或转移性肿瘤）。这些探针通过显示出红移的近红外吸收带和产生显著的光声信号，对疾病特异性生物标志物迅速做出反应。利用多光谱光声断层扫描（MSOT），我们可以使用 CX-OR 精确地定位小鼠药物诱导的肝损伤的焦点，以及使用 CX-OR 定位转移性肿瘤。这项工作表明，激活型光声生色团可能有潜力用于诊断和定位病灶，特别是更小和更深的病灶。
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