Heinzmann Kathrin, Carter Lukas M, Lewis Jason S, Aboagye Eric O
Department of Surgery and Cancer, Imperial College London, Du Cane Road, London, W12 0NN, UK.
Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Nat Biomed Eng. 2017 Sep;1(9):697-713. doi: 10.1038/s41551-017-0131-8. Epub 2017 Sep 12.
Complex molecular and metabolic phenotypes depict cancers as a constellation of different diseases with common themes. Precision imaging of such phenotypes requires flexible and tunable modalities capable of identifying phenotypic fingerprints by using a restricted number of parameters while ensuring sensitivity to dynamic biological regulation. Common phenotypes can be detected by in vivo imaging technologies, and effectively define the emerging standards for disease classification and patient stratification in radiology. However, for the imaging data to accurately represent a complex fingerprint, the individual imaging parameters need to be measured and analysed in relation to their wider spatial and molecular context. In this respect, targeted palettes of molecular imaging probes facilitate the detection of heterogeneity in oncogene-driven alterations and their response to treatment, and lead to the expansion of rational-design elements for the combination of imaging experiments. In this Review, we evaluate criteria for conducting multiplexed imaging, and discuss its opportunities for improving patient diagnosis and the monitoring of therapy.
复杂的分子和代谢表型将癌症描绘为具有共同主题的不同疾病的集合。对此类表型进行精准成像需要灵活且可调谐的模态，这些模态能够通过使用有限数量的参数来识别表型指纹，同时确保对动态生物调节的敏感性。常见表型可通过体内成像技术检测到，并有效定义放射学中疾病分类和患者分层的新兴标准。然而，为了使成像数据准确代表复杂指纹，需要在更广泛的空间和分子背景下测量和分析各个成像参数。在这方面，分子成像探针的靶向组合有助于检测癌基因驱动改变中的异质性及其对治疗的反应，并导致成像实验组合的合理设计元素得到扩展。在本综述中，我们评估了进行多重成像的标准，并讨论了其在改善患者诊断和治疗监测方面的机会。
