Department of Oral Surgery and Stomatology, ZMK School of Dental Medicine, University of Bern, Bern, Switzerland.
Department of Periodontology, International University of Catalonia, Barcelona, Spain.
Clin Oral Implants Res. 2018 Oct;29(10):1016-1024. doi: 10.1111/clr.13368. Epub 2018 Sep 28.
To investigate the impact of progressive bone loss in an experimental peri-implantitis model in the dog upon the implant stability quotient (ISQ) measured in the course of induced and spontaneous conditions of disease, and to evaluate the association between the clinical parameters and ISQ.
Seventy-two implants were placed in 12 Beagle dogs. Of these, 36 implants in six dogs were assessed during ligature-induced peri-implantitis (three timepoints) and at one timepoint following a period of spontaneous progression. The ISQ was recorded using resonance frequency analysis (RFA). Furthermore, the clinical peri-implant parameters were registered at four sites per implant at each timepoint. Marginal bone loss (MBL) was determined using computed tomography at four sites per implant and bone-to-implant contact (BIC) was assessed from histological samples. A linear regression model was estimated by generalized estimation equations (GEEs) in order to study the MBL-ISQ values at each measurement timepoint. Pearson's correlation test was applied.
None of the implants failed during the study period. At implant level, a strong negative correlation was found for all timepoints between ISQ and MBL (r = -0.58; p < 0.001). Accordingly, as follow-up progressed, lower ISQ and higher MBL values were observed. A prediction of MBL depending on the ISQ values and timepoints showed a decrease in one ISQ unit to be related to ~1 mm of MBL. Likewise, a statistically significant correlation was found between BIC and ISQ evaluated after spontaneous chronification of peri-implantitis (r = 0.34; p = 0.04). Nevertheless, the ISQ values failed to correlate to any of the clinical parameters recorded.
Resonance frequency analysis seems accurate in diagnosing progressive bone loss, as a statistically significant decrease in ISQ was recorded in the course of peri-implant disease. Nevertheless, the clinical relevance of this observation as a diagnostic tool is debatable, since implant stability remains high.
在犬实验性种植体周围炎模型中，研究进行性骨丧失对在诱导和自发疾病状态下测量的种植体稳定性指数（ISQ）的影响，并评估临床参数与 ISQ 之间的相关性。
将 72 个种植体植入 12 只比格犬体内。其中，36 个种植体（位于 6 只犬体内）在结扎诱导种植体周围炎期间（三个时间点）进行评估，并在自发进展期结束后一个时间点进行评估。使用共振频率分析（RFA）记录 ISQ。此外，在每个时间点，每个种植体的四个部位记录临床种植体周围参数。使用计算机断层扫描（CT）在每个种植体的四个部位确定边缘骨丧失（MBL），并从组织学样本评估骨-种植体接触（BIC）。通过广义估计方程（GEEs）估计线性回归模型，以研究每个测量时间点的 MBL-ISQ 值。应用 Pearson 相关检验。
在研究期间，没有种植体失败。在种植体水平上，所有时间点的 ISQ 与 MBL 之间均呈强负相关（r=-0.58；p<0.001）。因此，随着随访的进行，ISQ 降低，MBL 增加。根据 ISQ 值和时间点预测 MBL 显示，ISQ 降低一个单位与 MBL 约 1mm 相关。同样，在自发慢性种植体周围炎后评估的 BIC 与 ISQ 之间也发现了统计学显著相关性（r=0.34；p=0.04）。然而，ISQ 值与记录的任何临床参数均无相关性。
共振频率分析似乎能准确诊断进行性骨丧失，因为在种植体周围疾病过程中记录到 ISQ 有统计学意义的降低。然而，作为一种诊断工具，这种观察的临床相关性是有争议的，因为种植体稳定性仍然很高。
