静脉注射免疫球蛋白通过唾液酸化依赖机制预防实验性变应性支气管肺曲霉病。
Intravenous immunoglobulin protects from experimental allergic bronchopulmonary aspergillosis via a sialylation-dependent mechanism.
机构信息
Department of Medicine, University of Perugia, Perugia, Italy.
Research, CSL Behring AG, Bern, Switzerland.
出版信息
Eur J Immunol. 2019 Jan;49(1):195-198. doi: 10.1002/eji.201847774. Epub 2018 Oct 29.
PMID:30267564
Abstract
Intravenous immunoglobuin (IVIG) exerts protective effects in experimental allergic bronchopulmonary aspergillosis (ABPA) via a sialylation-dependent mechanism. The protection was associated with reduced recruitment of eosinophils, diminished goblet cell hyperplasia, suppressed Th2 and Th17 responses and reciprocally enhanced regulatory T cells and IL-10, and decreased IgE levels in the circulation.
摘要
静脉注射免疫球蛋白（IVIG）通过唾液酸化依赖的机制在实验性变应性支气管肺曲霉病（ABPA）中发挥保护作用。这种保护作用与嗜酸性粒细胞募集减少、杯状细胞增生减少、Th2 和 Th17 反应受抑制、调节性 T 细胞和 IL-10 增强以及循环中 IgE 水平降低有关。
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