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静脉注射免疫球蛋白通过唾液酸化依赖机制预防实验性变应性支气管肺曲霉病。

Intravenous immunoglobulin protects from experimental allergic bronchopulmonary aspergillosis via a sialylation-dependent mechanism.

机构信息

Department of Medicine, University of Perugia, Perugia, Italy.

Research, CSL Behring AG, Bern, Switzerland.

出版信息

Eur J Immunol. 2019 Jan;49(1):195-198. doi: 10.1002/eji.201847774. Epub 2018 Oct 29.

DOI:10.1002/eji.201847774
PMID:30267564
Abstract

Intravenous immunoglobuin (IVIG) exerts protective effects in experimental allergic bronchopulmonary aspergillosis (ABPA) via a sialylation-dependent mechanism. The protection was associated with reduced recruitment of eosinophils, diminished goblet cell hyperplasia, suppressed Th2 and Th17 responses and reciprocally enhanced regulatory T cells and IL-10, and decreased IgE levels in the circulation.

摘要

静脉注射免疫球蛋白（IVIG）通过唾液酸化依赖的机制在实验性变应性支气管肺曲霉病（ABPA）中发挥保护作用。这种保护作用与嗜酸性粒细胞募集减少、杯状细胞增生减少、Th2 和 Th17 反应受抑制、调节性 T 细胞和 IL-10 增强以及循环中 IgE 水平降低有关。

相似文献

[1]
Intravenous immunoglobulin protects from experimental allergic bronchopulmonary aspergillosis via a sialylation-dependent mechanism.

Eur J Immunol. 2018-10-29

[2]
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[3]
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Eur J Immunol. 2020-3-8

[4]
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Eur Respir J. 2024-5

[5]
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Eur J Immunol. 2014-5-2

[6]
Pattern recognition pathways leading to a Th2 cytokine bias in allergic bronchopulmonary aspergillosis patients.

Clin Exp Allergy. 2015-2

[7]
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Pharmacol Res. 2016-5-13

[8]
[Allergic bronchopulmonary aspergillosis (allergic bronchopulmonary fungal diseases)].

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[9]
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[10]
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引用本文的文献

[1]
IgG sialylation occurs in B cells pre antibody secretion.

Front Immunol. 2024

[2]
Humoral Immunity Against Aspergillus fumigatus.

Mycopathologia. 2023-10

[3]
Next-generation antibody-based therapies in neurology.

Brain. 2022-5-24

[4]
Sweet Rules: Linking Glycosylation to Antibody Function.

Exp Suppl. 2021

[5]
Immunoglobulin G Glycosylation Changes in Aging and Other Inflammatory Conditions.

Exp Suppl. 2021

[6]
Targeting B cells in the pre-phase of systemic autoimmunity globally interferes with autoimmune pathology.

iScience. 2021-9-1

[7]
Sialylated immunoglobulin G: a promising diagnostic and therapeutic strategy for autoimmune diseases.

Theranostics. 2021-3-13

[8]
High-Dose Intravenous Immunoglobulin in Severe Coronavirus Disease 2019: A Multicenter Retrospective Study in China.

Front Immunol. 2021

[9]
Clinical efficacy of intravenous immunoglobulin therapy in critical ill patients with COVID-19: a multicenter retrospective cohort study.

Clin Transl Immunology. 2020-10-14

[10]
Acute RNA Viral Encephalomyelitis and the Role of Antibodies in the Central Nervous System.

Viruses. 2020-9-5

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