Rajaram Ravi, Hofstetter Wayne L
Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
Thorac Surg Clin. 2018 Nov;28(4):473-480. doi: 10.1016/j.thorsurg.2018.07.004.
Patients with esophageal intestinal metaplasia, or Barrett's esophagus, may undergo dysplastic changes that eventually lead to invasive adenocarcinoma. Endoscopic therapy in the form of radiofrequency ablation and cryoablation has been described as a minimally invasive intervention to halt this sequence of dysplasia to carcinoma. Studies demonstrate that the use of radiofrequency ablation and cryoablation is highly successful at eradicating intestinal metaplasia and dysplasia and reducing the risk of disease progression. Furthermore, these modalities also may be used in combination with endoscopic mucosal resection, or as stand-alone therapy, for the treatment of intramucosal carcinoma, potentially circumventing the need for surgery.
患有食管肠化生（即巴雷特食管）的患者可能会发生发育异常变化，最终导致浸润性腺癌。射频消融和冷冻消融形式的内镜治疗已被描述为一种微创干预措施，以阻止这种发育异常到癌症的进程。研究表明，使用射频消融和冷冻消融在根除肠化生和发育异常以及降低疾病进展风险方面非常成功。此外，这些方法也可与内镜黏膜切除术联合使用，或作为单独疗法，用于治疗黏膜内癌，有可能避免手术的需要。
