Metabolic Signalling Group, School of Pharmacy and Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, Western Australia 6102, Australia.
Metabolic Signalling Group, School of Pharmacy and Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, Western Australia 6102, Australia.
Biochim Biophys Acta Gen Subj. 2019 Jan;1863(1):52-60. doi: 10.1016/j.bbagen.2018.09.019. Epub 2018 Sep 27.
ABC transporters have attracted considerable attention for their function as drug transporters in a broad range of tumours and are therefore considered as major players in cancer chemoresistance. However, less attention has been focused on their potential role as active players in cancer development and progression.
This review presents the evidence suggesting that ABC transporters might have a more active role in cancer other than the well known involvement in multidrug resistance and discusses the potential strategies to target each ABC transporter for a specific tumour setting.
Emerging evidence suggests that ABC transporters are able to transport bioactive molecules capable of playing key roles in tumour development. Characterization of the effects of these transporters in specific cancer settings opens the possibility for the development of personalized treatments.
A more targeted approach of ABC transporters should be implemented that considers which specific transporter is playing a major role in a particular tumour setting in order to achieve a more successful outcome for ABC transporters inhibitors in cancer therapy.
ABC 转运蛋白作为多种肿瘤中的药物转运蛋白引起了广泛关注，因此被认为是癌症化疗耐药的主要参与者。然而，它们在癌症发生和发展中的潜在作用尚未得到充分重视。
本文综述了 ABC 转运蛋白在癌症中的作用可能比其在多药耐药中的作用更为广泛的证据，并讨论了针对特定肿瘤环境靶向每个 ABC 转运蛋白的潜在策略。
新出现的证据表明，ABC 转运蛋白能够转运具有关键作用的生物活性分子，这些分子在肿瘤发展中。在特定的癌症环境中对这些转运蛋白的作用进行特征描述，为开发针对特定肿瘤的个体化治疗方法提供了可能性。
应该实施更有针对性的 ABC 转运蛋白方法，考虑在特定肿瘤环境中哪种特定转运蛋白起主要作用，以便在癌症治疗中更成功地应用 ABC 转运蛋白抑制剂。
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