Yang Shaofeng, Li Donghai
Inner Mongolia Medical University Hospital, Hohhot, China.
PeerJ. 2024 Dec 18;12:e18733. doi: 10.7717/peerj.18733. eCollection 2024.
Among women with cancer, breast cancer has surpassed lung cancer to become the most prevalent type of cancer globally. High-throughput sequencing of breast cancer tissues from many patients has revealed significant variations in circRNA expression across different types of breast cancer. Chemotherapy is currently a very important method for treating breast cancer; however, as the number of chemotherapy sessions increases and considering factors such as the patient's immune response, drug resistance has become a challenging issue in treating breast cancer. It is well known that drug resistance is associated with multiple factors, and different resistance mechanisms involve different roles of circRNA. This review consolidates literature from the past 5 years and addresses the shortcomings in the broad description of circRNA's role in breast cancer drug resistance. It categorizes and describes the drug resistance and its mechanisms in different types of breast cancer, as well as the roles of circRNA and signaling pathways in drug resistance.
在患有癌症的女性中，乳腺癌已超过肺癌，成为全球最常见的癌症类型。对众多患者的乳腺癌组织进行的高通量测序显示，不同类型乳腺癌中的环状RNA（circRNA）表达存在显著差异。化疗目前是治疗乳腺癌的一种非常重要的方法；然而，随着化疗疗程数的增加，并考虑到患者免疫反应等因素，耐药性已成为乳腺癌治疗中的一个具有挑战性的问题。众所周知，耐药性与多种因素相关，不同的耐药机制涉及circRNA的不同作用。本综述整合了过去5年的文献，探讨了在广泛描述circRNA在乳腺癌耐药性中的作用方面存在的不足。它对不同类型乳腺癌中的耐药性及其机制，以及circRNA和信号通路在耐药性中的作用进行了分类和描述。
