Ternowitz T
J Am Acad Dermatol. 1986 Dec;15(6):1191-9. doi: 10.1016/s0190-9622(86)70289-2.
Chemotactic activity of purified monocytes and polymorphonuclear leukocytes was studied in fifty patients with psoriasis vulgaris and in forty-five healthy individuals by an objective in vitro assay with the use of a 51Cr-labeling technic. Both monocytes and polymorphonuclear leukocytes showed a statistically significant increase in chemotactic response, which was positively correlated with disease activity but not with the extent of the cutaneous lesions. The chemotactic activity of monocytes correlated with that of polymorphonuclear leukocytes in the same patients. Exacerbation of psoriasis was preceded by a rapid increase of polymorphonuclear leukocyte chemotaxis, and a decline of chemotaxis occurred during clinical improvement. The psoriatic leukocytes were 22% more sensitive than normal leukocytes to leukotriene B4 than to N-formyl-methionyl-leucyl-phenylalanine. Psoriatic plasma showed chemotaxis-enhancing properties, but only in patients with widespread cutaneous lesions. Additionally, monocyte and polymorphonuclear leukocyte chemotaxis was studied in twenty patients with pustular psoriasis and in fifteen patients with psoriatic arthritis. The chemotactic profiles in pustular psoriasis were different from those in psoriasis vulgaris. Patients with pustular psoriasis had significantly higher polymorphonuclear leukocyte chemotaxis than patients with psoriasis vulgaris, but the chemotactic activity of monocytes was normal. The presence of seronegative arthritis had no influence on chemotactic activity of psoriatic leukocytes.
采用51Cr标记技术的客观体外试验，对50例寻常型银屑病患者和45名健康个体的纯化单核细胞和多形核白细胞的趋化活性进行了研究。单核细胞和多形核白细胞的趋化反应均有统计学意义的增加，这与疾病活动呈正相关，但与皮肤病变范围无关。同一患者中，单核细胞的趋化活性与多形核白细胞的趋化活性相关。银屑病加重之前多形核白细胞趋化性迅速增加，临床改善期间趋化性下降。银屑病白细胞对白三烯B4的敏感性比正常白细胞对N-甲酰甲硫氨酰亮氨酰苯丙氨酸的敏感性高22%。银屑病血浆具有趋化增强特性，但仅在有广泛皮肤病变的患者中出现。此外，还对20例脓疱型银屑病患者和15例银屑病关节炎患者的单核细胞和多形核白细胞趋化性进行了研究。脓疱型银屑病的趋化特征与寻常型银屑病不同。脓疱型银屑病患者的多形核白细胞趋化性显著高于寻常型银屑病患者，但单核细胞的趋化活性正常。血清阴性关节炎的存在对银屑病白细胞的趋化活性没有影响。
