Ternowitz T
J Am Acad Dermatol. 1987 Jun;16(6):1169-75. doi: 10.1016/s0190-9622(87)70152-2.
The chemotactic activity of purified monocytes and neutrophils was studied in twenty-two psoriatic patients prior to the initiation of psoralens plus ultraviolet A (PUVA) or anthralin therapy and during the treatment. Patients with untreated, active psoriasis had increased chemotactic response of their monocytes and neutrophils to N-formyl-methionyl-leucyl-phenylalanine. Plasma from untreated psoriasis patients had an enhanced chemotactic activity toward neutrophils from persons without psoriasis. Treatment with PUVA or anthralin resulted in a progressive clearing of psoriatic lesions and in a significant depression of leukocyte chemotaxis 2 weeks after the start of the respective therapy. The chemotactic activity of both monocytes and neutrophils was normalized after 4 weeks of anthralin therapy and after 6 weeks of PUVA treatment. The chemotaxis-enhancing properties of plasma from psoriasis patients returned to normal values already after 2 weeks of treatment.
在22例银屑病患者中，研究了纯化单核细胞和中性粒细胞的趋化活性，这些患者在开始补骨脂素加紫外线A（PUVA）或蒽林治疗之前以及治疗期间进行了相关研究。未经治疗的活动性银屑病患者的单核细胞和中性粒细胞对N-甲酰甲硫氨酰亮氨酰苯丙氨酸的趋化反应增强。未经治疗的银屑病患者的血浆对无银屑病患者的中性粒细胞具有增强的趋化活性。PUVA或蒽林治疗导致银屑病皮损逐渐消退，且在各自治疗开始2周后白细胞趋化性显著降低。蒽林治疗4周后以及PUVA治疗6周后，单核细胞和中性粒细胞的趋化活性均恢复正常。银屑病患者血浆的趋化增强特性在治疗2周后就已恢复到正常值。
