表面活性离子液体的水溶液：提高三萜酸溶解度及其从生物质中提取的显著替代溶剂。
Aqueous solutions of surface-active ionic liquids: remarkable alternative solvents to improve the solubility of triterpenic acids and their extraction from biomass.
作者信息
de Faria Emanuelle L P, Shabudin Selesa V, Claúdio Ana Filipa M, Válega Mónica, Domingues Fernando M J, Freire Carmen S R, Silvestre Armando J D, Freire Mara G
机构信息
CICECO - Aveiro Institute of Materials, Chemistry Department, University of Aveiro, University Campus of Santiago, 3810-193 Aveiro, Portugal.
QOPNA - Chemistry Department, University of Aveiro, University Campus of Santiago, 3810-193 Aveiro, Portugal.
出版信息
ACS Sustain Chem Eng. 2017 Aug 7;5(8):7344-7351. doi: 10.1021/acssuschemeng.7b01616. Epub 2017 Jul 11.
Triterpenic acids (TTAs) are well known for their relevant biological properties and have been facing an increasing interest for nutraceutical and pharmaceutical applications. To overcome the concerns associated to the commonly used volatile organic solvents for their extraction from biomass, here we investigate the potential of aqueous solutions of ionic liquids (ILs) as alternative solvents. The solubility of ursolic acid (UA) was firstly determined in several aqueous solutions of ILs (hydrotropes or surface-active) at 30°C to appraise the dissolution phenomenon. Conventional surfactants were also investigated for comparison purposes. The collected data reveal a remarkable enhancement in the solubility of UA (8 orders of magnitude) in surface-active ILs aqueous solutions when compared to pure water. Afterwards, the potential of these ILs aqueous solutions was confirmed by their use in the extraction of TTAs from apple peels. Total extractions yield of TTAs of 2.62 wt.% were obtained using aqueous solutions of surface-active ILs at moderate conditions, overwhelming the extraction yields of 2.48 wt.% obtained with chloroform and 1.37 wt.% with acetone using similar conditions.
三萜酸（TTAs）因其相关的生物学特性而闻名，并且在营养保健品和制药应用方面越来越受到关注。为了克服与从生物质中提取它们时常用的挥发性有机溶剂相关的问题，在此我们研究离子液体（ILs）水溶液作为替代溶剂的潜力。首先在30°C下测定了熊果酸（UA）在几种离子液体水溶液（助溶剂或表面活性剂）中的溶解度，以评估溶解现象。为了进行比较，还研究了传统表面活性剂。收集的数据显示，与纯水相比，UA在表面活性离子液体水溶液中的溶解度显著提高（8个数量级）。之后，通过将这些离子液体水溶液用于从苹果皮中提取三萜酸，证实了它们的潜力。在温和条件下使用表面活性离子液体水溶液获得的三萜酸总提取产率为2.62 wt.%，超过了在类似条件下用氯仿获得的2.48 wt.%和用丙酮获得的1.37 wt.%的提取产率。
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