Janas J D, Stellar J R
Harvard University, Boston, Massachusetts.
Behav Neurosci. 1987 Dec;101(6):832-45. doi: 10.1037//0735-7044.101.6.832.
Unilateral frontal-plane knife-cut lesions were made in the anterior medial forebrain bundle ipsilateral to a lateral hypothalamic self-stimulation electrode. Behavioral effects of the knife cut on self-stimulation reward and operant performance capacity were measured via the reward summation function method. Knife cuts placed at the level of the anterior commissure were ineffective in altering reward or motor/performance capacity, whereas knife cuts just posterior in the caudal lateral preoptic area degraded reward and sometimes impaired motor/performance capacity. In a second experiment, knife cuts placed posterior to the ventral tegmental area were ineffective unless they intruded on the ventral tegmental area itself. Several small knife cuts placed just anterior to the ventral tegmental were effective in reducing self-stimulation reward. The results are discussed in terms of the anatomical substrate of lateral hypothalamic self-stimulation reward and as a first step in a larger mapping study.
在与外侧下丘脑自我刺激电极同侧的前脑内侧束进行单侧额平面刀切损伤。通过奖励总和函数法测量刀切对自我刺激奖励和操作性行为能力的行为影响。在前连合水平进行的刀切对改变奖励或运动/行为能力无效，而在尾侧外侧视前区稍后方进行的刀切会降低奖励，有时还会损害运动/行为能力。在第二个实验中，在腹侧被盖区后方进行的刀切无效，除非侵入腹侧被盖区本身。在腹侧被盖区稍前方进行的几个小刀切有效地减少了自我刺激奖励。根据外侧下丘脑自我刺激奖励的解剖学基础对结果进行了讨论，并作为更大范围映射研究的第一步。
