rs9939609-FTO 与墨西哥恰帕斯州玛雅社区女性代谢综合征成分的关联。
Association of rs9939609-FTO with metabolic syndrome components among women from Mayan communities of Chiapas, Mexico.
机构信息
Health Department, El Colegio de La Frontera Sur, San Cristóbal de Las Casas, Chiapas, Mexico.
National Council for Science and Technology, Postgraduate College Campus Puebla, Puebla, Mexico.
出版信息
J Physiol Anthropol. 2021 Aug 28;40(1):11. doi: 10.1186/s40101-021-00259-9.
BACKGROUND
Metabolic syndrome (MetS) is a complex cluster of risk factors, considered as a polygenic and multifactorial entity. The objective of this study was to determine the association of rs9939609-FTO polymorphism and MetS components in adult women of Mayan communities of Chiapas.
METHODS
In a cross-sectional study, sociodemographic, anthropometric, clinical, and biochemical data were obtained from 291 adult women from three regions of Chiapas, Mexico. The prevalence of MetS and the allele and genotype frequencies of the rs9939609-FTO were estimated. Multivariate logistic regression models were used to assess the association of the single nucleotide polymorphism (SNP) with each of the MetS components.
RESULTS
The MetS prevalence was 60%. We found a statistically significant association between rs9939609-FTO and hyperglycemia in the dominant model (OR 2.6; 95% CI 1.3-5.3; p = 0.007).
CONCLUSIONS
Women from Mayan communities of Chiapas presented a high prevalence of MetS and a relevant association of the FTO variant with hyperglycemia. This is the first study carried out in these Mayan indigenous communities from Chiapas.
背景
代谢综合征（MetS）是一组复杂的危险因素，被认为是一种多基因和多因素的实体。本研究的目的是确定 rs9939609-FTO 多态性与恰帕斯州梅萨纳社区成年女性代谢综合征成分之间的关联。
方法
在一项横断面研究中，从墨西哥恰帕斯州三个地区的 291 名成年女性中获得了社会人口统计学、人体测量学、临床和生化数据。估计了 MetS 的患病率以及 rs9939609-FTO 的等位基因和基因型频率。多变量逻辑回归模型用于评估 SNP 与每个代谢综合征成分的关联。
结果
MetS 的患病率为 60%。我们发现 rs9939609-FTO 与显性模型中的高血糖之间存在统计学显著关联（OR 2.6；95%CI 1.3-5.3；p=0.007）。
结论
恰帕斯州梅萨纳社区的女性表现出较高的 MetS 患病率，并且 FTO 变异与高血糖之间存在显著关联。这是在这些恰帕斯州的梅萨纳土著社区进行的第一项研究。
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