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一期修复成人主动脉缩窄及合并心脏疾病:升主动脉至腹主动脉外旁路与心脏手术联合治疗。

One-Stage Repair of Adult Aortic Coarctation and Concomitant Cardiac Diseases: Ascending to Abdominal Aorta Extra-Anatomical Bypass Combined with Cardiac Surgery.

机构信息

Beijing Aortic Disease Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

Beijing Aortic Disease Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

出版信息

Heart Lung Circ. 2019 Nov;28(11):1740-1746. doi: 10.1016/j.hlc.2018.08.024. Epub 2018 Sep 22.

Abstract

BACKGROUND

To evaluate one-stage repair with ascending to abdominal aorta extra-anatomical bypass combined with cardiac surgery for adult aortic coarctation (COA) concomitant with cardiac diseases.

METHODS

Between February 2009 and September 2016, 24 consecutive patients (79.17% male, mean age 36.04±13.67years) with COA and concomitant cardiac diseases underwent one-stage repair (ascending to abdominal aorta extra-anatomical bypass combined with cardiac surgery). Two (2) patients who underwent off-pump coronary artery surgery combined with ascending to abdominal aorta bypass did not require cardiopulmonary bypass. Twenty-two (22) patients underwent one-stage repair under cardiopulmonary bypass.

RESULTS

No in-hospital mortality was observed. There was a significant reduction in baseline systolic blood pressure from 159.80±23.58 to 127.0±6.86mmHg. Mean upper-lower limb blood gradient pressure decreased significantly from 37.80±8.73 to 11.47±2.12mmHg after surgery. Two (2) patients required prolonged mechanical ventilation for respiratory dysfunction. One patient needed temporary continuous renal replacement therapy. No re-exploration for bleeding and gastrointestinal complications was needed. There was no postoperative paraplegia or permanent neurological abnormalities. Grafts were patent for all patients and no graft-related complications were observed in the hospital. Median follow-up was 41.50 months (interquartile range [IQR] 16.75-64.50 months) and 6-year survival was 76.39%. Median number of antihypertensive drugs was 0 (IQR 0-1), which was a significant reduction compared with preoperative drugs (2, IQR 1-3).

CONCLUSIONS

Ascending to abdominal extra-anatomical aorta bypass combined with cardiac surgery is a safe and effective one-stage repair technique for patients with COA concomitant with cardiac diseases.

摘要

背景

评估升主动脉至腹主动脉外旁路联合心脏手术一期修复成人主动脉缩窄(COA)合并心脏疾病的效果。

方法

2009 年 2 月至 2016 年 9 月,24 例连续 COA 合并心脏疾病患者(79.17%为男性,平均年龄 36.04±13.67 岁)接受了一期修复(升主动脉至腹主动脉外旁路联合心脏手术)。2 例(2)行非体外循环冠状动脉旁路移植术联合升主动脉旁路者无需体外循环。22 例(22)患者在体外循环下行一期修复。

结果

无院内死亡。术前收缩压从 159.80±23.58mmHg 降至 127.0±6.86mmHg,有显著降低。术后上下肢血压梯度从 37.80±8.73mmHg 降至 11.47±2.12mmHg,有显著降低。2 例(2)患者因呼吸功能障碍需要长时间机械通气。1 例患者需要临时连续肾脏替代治疗。无再次探查出血和胃肠道并发症。无术后截瘫或永久性神经功能异常。所有患者的移植物通畅,无移植相关并发症。中位随访时间为 41.50 个月(四分位距 16.75-64.50 个月),6 年生存率为 76.39%。中位降压药物数量为 0(四分位距 0-1),与术前相比明显减少(2,四分位距 1-3)。

结论

升主动脉至腹主动脉外旁路联合心脏手术是一种安全有效的一期修复技术,适用于 COA 合并心脏疾病的患者。

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