c-fos基因表达失调会干扰转基因小鼠的正常骨骼发育。
Deregulated c-fos expression interferes with normal bone development in transgenic mice.
作者信息
Rüther U, Garber C, Komitowski D, Müller R, Wagner E F
出版信息
Nature. 1987;325(6103):412-6. doi: 10.1038/325412a0.
DOI:10.1038/325412a0
PMID:3027573
Abstract
Transgenic mice were generated expressing c-fos genes under the control of the human metallothionein promoter. Although high levels of c-fos messenger RNA were detectable in a variety of tissues, deregulated c-fos expression specifically interfered with normal bone development without inducing malignant tumours.
摘要
构建了在人金属硫蛋白启动子控制下表达c-fos基因的转基因小鼠。尽管在多种组织中都能检测到高水平的c-fos信使核糖核酸，但c-fos表达失调会特异性地干扰正常骨骼发育，而不会诱发恶性肿瘤。
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